Invert Sugar (10%) is a sterile, non-pyrogenic, hypertonic intravenous solution containing a mixture of equal parts of dextrose and fructose (levulose). It is a readily metabolizable carbohydrate source that provides calories and fluid. Unlike dextrose alone, it is metabolized independently of insulin, making it advantageous in conditions of insulin resistance or stress. It is primarily used for parenteral nutrition and fluid/calorie replacement in patients unable to tolerate oral feeding.
Adult: Usual dose: 500 mL to 3000 mL per day. Infusion rate: Should not exceed 0.5 g of fructose per kg body weight per hour (e.g., ~500 mL of 10% solution per hour for a 70 kg adult). Total daily caloric intake from carbohydrates should be individualized.
Note: For intravenous use only. Must be administered via a central or large peripheral vein to minimize risk of thrombophlebitis. Use sterile technique. The solution is hypertonic and should be infused slowly. Check for clarity and seal integrity before use. Do not administer if particulate matter or discoloration is present.
Provides a source of carbohydrates (dextrose and fructose) for metabolic energy production. Dextrose is metabolized via the glycolytic pathway and the citric acid cycle, requiring insulin for cellular uptake in most tissues. Fructose is metabolized independently of insulin, primarily in the liver via the fructokinase pathway, making it a useful energy source during states of insulin resistance, stress, or trauma.
Pregnancy: Category C: Animal reproduction studies have not been conducted. Should be used during pregnancy only if clearly needed. Can be used for nutritional support in hyperemesis gravidarum.
Driving: No effect on ability to drive and use machines.
| Insulin | Additive hyperglycemic effect may require increased insulin dosage. Close monitoring of blood glucose is essential. | Major |
| Corticosteroids (e.g., Prednisolone, Dexamethasone) | May exacerbate hyperglycemia. Increased monitoring required. | Moderate |
| Diuretics (especially Thiazides, Loop diuretics) | May worsen glucose tolerance and electrolyte imbalances (hypokalemia). | Moderate |
| Phenytoin | Invert sugar solutions may cause precipitation of phenytoin. Do not mix in the same IV line. | Major |
| Blood products | Should not be administered through the same intravenous set due to risk of pseudoagglutination. | Major |
Same composition (Invert Sugar (10%)), different brands: