A fixed-dose combination (FDC) of a sympathomimetic decongestant (Pseudoephedrine), a first-generation sedating antihistamine (Chlorpheniramine Maleate), and a centrally-acting antitussive (Dextromethorphan Hydrobromide). It is primarily used for the symptomatic relief of cough and cold, providing decongestion, reduction of allergic symptoms, and suppression of non-productive cough. The combination is widely used in India, though its FDC status has been under regulatory scrutiny.
Adult Dosage: Typically: 10 ml syrup or 1 tablet (containing Pseudoephedrine 60 mg, Chlorpheniramine Maleate 4 mg, Dextromethorphan HBr 15 mg) every 6-8 hours. Maximum: 4 doses in 24 hours. Always follow specific brand prescribing information.
Instructions: Oral administration. Syrup: Use measuring cup/spoon. Can be taken with or without food. Taking with food may reduce GI upset. Maintain adequate fluid intake. Do not crush or chew sustained-release formulations (if any).
The combination provides multi-modal symptomatic relief. Pseudoephedrine acts as a decongestant by stimulating alpha-adrenergic receptors in the nasal mucosa, causing vasoconstriction and reduced edema. Chlorpheniramine is a competitive H1-histamine receptor antagonist, reducing allergic symptoms like rhinorrhea and sneezing, with significant CNS penetration causing sedation. Dextromethorphan suppresses the cough reflex by acting on the medullary cough center, primarily via NMDA receptor antagonism and sigma-1 receptor agonism.