Potassium Citrate (1100mg/5ml) + Magnesium Citrate (375mg/5ml) + Vitamin B6 (Pyridoxine) (20mg/5ml) (Medical Monograph)

Overview

A fixed-dose combination oral solution primarily used as a urinary alkalinizer and electrolyte replenisher. Potassium citrate provides potassium and citrate ions, magnesium citrate supplies magnesium, and Vitamin B6 (Pyridoxine) aids in magnesium absorption and cellular metabolism. It is clinically significant for managing hypocitraturic calcium oxalate nephrolithiasis, renal tubular acidosis, and hypokalemia/hypomagnesemia, particularly in the Indian context where dietary deficiencies and recurrent kidney stones are prevalent.

1. Potassium Citrate: Dissociates to provide potassium ions and citrate. Citrate is metabolized systemically to bicarbonate, raising blood and urine pH (alkalinization). In urine, increased citrate binds calcium, reducing calcium oxalate and phosphate supersaturation, inhibiting stone formation. Potassium helps correct hypokalemia. 2. Magnesium Citrate: Provides magnesium ions; acts as a physiologic calcium channel blocker, reducing calcium oxalate crystal growth and aggregation in urine. Also corrects hypomagnesemia. 3. Vitamin B6 (Pyridoxine): A cofactor in oxalate metabolism; deficiency can lead to hyperoxaluria. It enhances intestinal absorption of magnesium and is involved in neurotransmitter synthesis.