A fixed-dose combination oral liquid primarily indicated for the symptomatic relief of cough and associated symptoms of upper respiratory tract infections and allergic conditions. It combines a decongestant (Phenylephrine), a first-generation sedating antihistamine (Chlorpheniramine), and a centrally-acting antitussive (Dextromethorphan). This combination is widely used in the Indian market for managing productive and non-productive cough with nasal congestion, rhinorrhea, and sneezing.
Adult Dosage: 10 ml (2 teaspoonfuls) three to four times daily. Maximum: 40 ml per day.
Instructions: Shake the bottle well before use. Use the measuring cup or spoon provided. Can be taken with or without food. Taking with food may reduce GI upset. Maintain adequate hydration.
The combination works synergistically to relieve multiple symptoms of cough and cold. Phenylephrine acts as a selective alpha-1 adrenergic receptor agonist, causing vasoconstriction in the nasal mucosa, reducing edema and congestion. Chlorpheniramine is a competitive inverse agonist at peripheral and central H1 receptors, inhibiting histamine-mediated symptoms like sneezing and rhinorrhea, and causing sedation. Dextromethorphan acts centrally on the cough center in the medulla oblongata, raising the threshold for coughing, likely through NMDA receptor antagonism and sigma-1 receptor agonism.