Oxetacaine (10mg/5ml) + Aluminium Hydroxide (600mg/5ml) + Magnesium (300mg/5ml) + Simethicone (25mg/5ml) (Medical Monograph)

Overview

A quadruple-action oral suspension for the symptomatic management of hyperacidity, gastroesophageal reflux disease (GERD), and associated dyspepsia. It combines a potent local anesthetic (oxetacaine) for rapid pain relief, two antacids (aluminium hydroxide and magnesium hydroxide) for acid neutralization, and an antiflatulent (simethicone) for gas relief. It is a first-line therapy for immediate relief of acid-peptic symptoms in the Indian outpatient setting.

1. Oxetacaine: A potent surface anesthetic that blocks sodium channels in the neuronal membrane of the esophageal and gastric mucosa, providing rapid relief from pain and burning sensation. 2. Aluminium Hydroxide & Magnesium Hydroxide: Non-systemic antacids that react with and neutralize hydrochloric acid in the gastric lumen, raising the pH. They also adsorb pepsin and bile salts. 3. Simethicone: A physiologically inert antifoaming agent that reduces the surface tension of gas bubbles in the GI tract, causing them to coalesce and be more easily expelled via belching or flatus.