Methylcobalamin (1500mcg) + Vitamin B6 (Pyridoxine) (100mg) + Nicotinamide (100mg) (Medical Monograph)

Overview

A fixed-dose combination of three essential B vitamins used primarily for the treatment and management of neuropathic pain, diabetic neuropathy, and vitamin B deficiencies. Methylcobalamin is the active form of Vitamin B12, crucial for nerve health and myelin synthesis. Pyridoxine (B6) is involved in neurotransmitter synthesis and nerve function. Nicotinamide (a form of Vitamin B3) supports cellular energy metabolism and neuronal health. This combination is widely prescribed in India for its neurotropic and analgesic effects in peripheral neuropathies.

The combination exerts synergistic neurotropic, analgesic, and neuroprotective effects. Methylcobalamin is essential for the synthesis of S-adenosylmethionine (SAMe), crucial for myelin formation and maintenance. It also promotes nerve regeneration and reduces abnormal nerve discharge. Pyridoxine, as pyridoxal phosphate (PLP), is a cofactor in the synthesis of neurotransmitters (GABA, serotonin, dopamine) and helps reduce homocysteine levels. Nicotinamide, as NAD+, is vital for cellular energy (ATP) production, DNA repair via PARP enzymes, and has anti-inflammatory and neuroprotective properties.