Methylcobalamin (1000mcg) + Vitamin B6 (Pyridoxine) (100mg) + Nicotinamide (100mg) (Medical Monograph)

Overview

A fixed-dose combination of three essential B vitamins used primarily for the treatment and prevention of neuropathies, nutritional deficiencies, and certain metabolic disorders. Methylcobalamin is the active, coenzyme form of Vitamin B12, crucial for nerve health and hematopoiesis. Pyridoxine (B6) is a cofactor in amino acid metabolism and neurotransmitter synthesis. Nicotinamide (a form of Vitamin B3) is essential for NAD+ synthesis, cellular energy production, and DNA repair. This combination is extensively prescribed in India for diabetic peripheral neuropathy, vitamin B deficiency syndromes, and as supportive therapy in various neurological conditions.

The combination acts synergistically to correct deficiencies, support nerve myelination, modulate pain pathways, and improve neuronal metabolism. Methylcobalamin is a cofactor for methionine synthase (converting homocysteine to methionine) and L-methylmalonyl-CoA mutase. This supports myelin synthesis, nucleic acid production, and reduces neurotoxic homocysteine. Pyridoxine, as PLP, is a cofactor for over 140 enzymes, including those involved in neurotransmitter synthesis (GABA, serotonin, dopamine), heme synthesis, and homocysteine metabolism (via cystathionine beta-synthase). Nicotinamide is a precursor for NAD+ and NADP+, critical coenzymes in cellular respiration (glycolysis, TCA cycle, oxidative phosphorylation), DNA repair via PARP enzymes, and cellular antioxidant defense.