Methylcobalamin (1000mcg) + Niacinamide (100mg) + Vitamin B6 (Pyridoxine) (100mg) (Medical Monograph)

Overview

A fixed-dose combination of three essential B vitamins used primarily for the treatment and prevention of severe B-complex deficiencies, peripheral neuropathies (especially diabetic neuropathy), and certain hematological conditions. Methylcobalamin is the active, coenzyme form of Vitamin B12, Niacinamide is the amide form of Vitamin B3, and Pyridoxine is Vitamin B6. This combination is widely prescribed in India for neuropathic pain, nutritional supplementation in chronic diseases, and as adjunctive therapy in various neurological disorders.

The combination acts synergistically to support nerve health, hematopoiesis, and cellular metabolism. Methylcobalamin is a cofactor for methionine synthase (homocysteine metabolism) and L-methylmalonyl-CoA mutase (myelin synthesis). Niacinamide is a precursor for NAD and NADP, crucial for redox reactions and DNA repair. Pyridoxine (as PLP) is a cofactor for over 100 enzymes involved in neurotransmitter synthesis (GABA, serotonin, dopamine), hemoglobin formation, and amino acid metabolism.