Meglumine Diatrizoate (0.66gm) + Sodium Diatrizoate (0.1gm) (Medical Monograph)

Overview

Meglumine Diatrizoate (0.66gm) + Sodium Diatrizoate (0.1gm) is a sterile, aqueous, ionic, high-osmolality iodinated contrast medium (HOCM) for intravascular administration. It is a combination of a meglumine salt and a sodium salt of diatrizoic acid, providing a total iodine concentration of approximately 370 mg I/mL. This composition is specifically formulated to reduce the risk of ventricular fibrillation and other cardiac arrhythmias compared to purely sodium-based ionic contrast media, while maintaining good radiographic density. It is widely used in diagnostic imaging procedures across India.

Diatrizoate salts are radiopaque substances. Iodine (atomic number 53) has a high atomic mass, which effectively absorbs X-rays. When injected into blood vessels, body cavities, or ducts, it attenuates (blocks) X-rays to a much greater degree than surrounding tissues, creating a contrast between the lumen containing the agent and the adjacent tissue. This allows visualization of internal structures during radiographic procedures like angiography, urography, and hysterosalpingography.