Lidocaine (1%) + Liver Fraction 2 Derived From Fresh Liver 01 (8g) (Medical Monograph)

Overview

A topical combination product containing the local anesthetic Lidocaine (1% w/w) and a hepatoprotective agent, Liver Fraction 2 (8g per 100g). Lidocaine provides rapid, reversible nerve blockade for pain relief, while Liver Fraction 2, derived from fresh porcine liver, is believed to provide essential amino acids, vitamins, and co-factors that may support cellular regeneration and metabolic function in damaged tissues. This combination is primarily used for symptomatic relief of pain and itching associated with various anorectal and dermatological conditions, with a proposed ancillary benefit of supporting tissue healing.

Uses

  • Symptomatic relief of pain and itching in hemorrhoids (piles)
  • Pruritus ani (anal itching)
  • Pain associated with anal fissures

Side Effects

  • Transient local burning, stinging, or irritation at the application site
  • Erythema (redness)
  • Localized edema (swelling)

Detailed Pharmacology

Lidocaine: Blocks voltage-gated sodium channels on neuronal membranes, inhibiting the initiation and conduction of nerve impulses, leading to reversible loss of sensation (anesthesia). Liver Fraction 2: Provides a complex of amino acids, nucleotides, vitamins (B-group), and other cellular components derived from liver tissue. It is postulated to act as a local nutrient substrate, supporting protein synthesis and cellular repair in inflamed or damaged tissues, potentially reducing inflammation and promoting healing.

Available Brands in India

BrandManufacturerPrice
Proctosedyl-B Sanofi India Limited ₹120 - ₹180 for 10g tube
Lignox-L Troikaa Pharmaceuticals Ltd. ₹100 - ₹150 for 10g tube
Lidohep Indoco Remedies Ltd. ₹90 - ₹140 for 10g tube
Proctoheal-L Healing Pharma India Pvt. Ltd. ₹80 - ₹130 for 10g tube