Insulin Isophane/NPH (70%) + Human Insulin/Soluble Insulin (30%) (Medical Monograph)

Overview

A biphasic isophane insulin preparation containing 70% intermediate-acting insulin isophane (NPH) and 30% short-acting human insulin (regular soluble insulin). It is a premixed insulin analogue designed to provide both prandial (meal-time) and basal (background) glycemic control in a single injection. It is a suspension for injection and must be resuspended by gentle rolling before administration.

Insulin is an endogenous hormone produced by pancreatic beta cells. This combination preparation mimics both prandial and basal insulin secretion. The soluble insulin (30%) component acts rapidly to control postprandial glucose rise, while the isophane/NPH insulin (70%) component provides a prolonged intermediate action to control basal glucose levels between meals and overnight.