A sterile suspension of adsorbed, purified diphtheria, tetanus, and pertussis toxoids for active immunization. It is a triple antigen vaccine that stimulates the immune system to produce protective antibodies against diphtheria, tetanus, and pertussis (whooping cough). It is a critical component of the Universal Immunization Programme (UIP) in India for primary immunization in infants and children.
Adult Dosage: NOT RECOMMENDED for adults. For adults and children ≥7 years, Tdap (reduced diphtheria and pertussis antigen) is used.
Instructions: Shake the vial/vial or pre-filled syringe well before use. Administer by deep intramuscular injection, preferably in the anterolateral aspect of the mid-thigh in infants or the deltoid muscle in older children. Do not administer intravenously, intradermally, or subcutaneously. Use a separate, sterile syringe and needle for each patient.
Contains formaldehyde-inactivated toxins (toxoids) from Corynebacterium diphtheriae, Clostridium tetani, and Bordetella pertussis. Upon intramuscular administration, the adsorbed toxoids are taken up by antigen-presenting cells, processed, and presented to helper T-cells. This stimulates B-lymphocytes to proliferate and differentiate into memory B-cells and antibody-producing plasma cells. The produced neutralizing antibodies (IgG) provide protection against the respective diseases.