Cyproheptadine (2mg/5ml) + Tricholine Citrate (275mg/5ml) + Sorbitol (3gm/5ml)

🩺 Quick Overview

A triple-action oral liquid formulation combining a first-generation antihistamine (Cyproheptadine) with a lipotropic agent (Tricholine Citrate) and an osmotic laxative (Sorbitol). Primarily used in the Indian context as an appetite stimulant and hepatoprotective tonic, especially in pediatric and geriatric populations for weight gain and liver function support. It addresses anorexia, undernutrition, and associated symptoms like early satiety and constipation.

Medical Uses

  • Appetite stimulation and weight gain in underweight individuals, especially children
  • Adjunctive therapy in malnutrition and failure to thrive
  • Hepatoprotection and as a lipotropic agent in fatty liver disease, hepatic steatosis

Side Effects

  • Drowsiness, sedation, somnolence
  • Dry mouth (xerostomia)
  • Dry nose/throat
  • Increased appetite and weight gain
  • Mild dizziness
  • Constipation or diarrhea (Sorbitol effect is dose-dependent)
  • Blurred vision
  • Gastrointestinal discomfort (nausea, epigastric pain)

💊 Dosage & Administration

Adult Dosage: 5 ml to 10 ml (1 to 2 teaspoonfuls) two to three times daily, preferably before meals. Max: 30 ml/day.

Instructions: Shake the bottle well before use. Use the calibrated measuring device provided. Take orally, preferably 15-30 minutes before meals for optimal appetite stimulation. Can be taken with or without food. Do not mix with other liquids. Maintain adequate fluid intake due to Sorbitol content.

🏭 Available Brands in India

Hepahill Cipla Ltd Appetrol Sun Pharmaceutical Industries Ltd. Apeton Mankind Pharma Ltd. Cyproheptine Plus Aristo Pharmaceuticals Pvt. Ltd. Appecon Alkem Laboratories Ltd.

Mechanism of Action

The combination works synergistically. Cyproheptadine antagonizes histamine H1 and serotonin (5-HT2) receptors in the hypothalamic appetite center, stimulating hunger. Its antiserotonergic effect may also reduce early satiety. Tricholine Citrate acts as a lipotropic agent, providing choline which is essential for hepatic fat metabolism (as a methyl donor) and phospholipid synthesis, aiding in liver decongestion and fat mobilization. Sorbitol, a hyperosmotic agent, draws water into the intestinal lumen, softening stools and stimulating peristalsis, relieving constipation often associated with poor dietary habits.