Cyproheptadine (2mg/5ml) + Tricholine Citrate (275mg/5ml) + Sorbitol (2gm/5ml)

🩺 Quick Overview

A triple-action oral liquid formulation combining a first-generation antihistamine (Cyproheptadine), a lipotropic agent and choleretic (Tricholine Citrate), and an osmotic laxative (Sorbitol). Primarily used in the Indian context as an appetite stimulant and digestive tonic, especially in pediatric and geriatric populations for weight gain and management of functional dyspepsia. It addresses poor appetite, indigestion, and associated symptoms like bloating and constipation.

Medical Uses

  • Poor appetite (Anorexia) of non-organic origin
  • Underweight/ Failure to thrive in children
  • Functional dyspepsia with bloating and flatulence
  • As an adjunct in convalescence for nutritional support

Side Effects

  • Drowsiness, sedation
  • Dry mouth (xerostomia)
  • Dizziness
  • Increased appetite and weight gain
  • Mild abdominal discomfort or cramping (sorbitol)
  • Blurred vision
  • Constipation or diarrhea (variable effect)

💊 Dosage & Administration

Adult Dosage: 5 ml to 10 ml (1-2 teaspoonfuls) three times a day, before meals. Max: 30 ml/day.

Instructions: Shake well before use. Administer orally, preferably before meals to stimulate appetite. Use the calibrated measuring device provided. Can be taken with or without water. Do not mix with other liquids unless advised.

🏭 Available Brands in India

CYPOLIN PLUS Cipla Ltd. APETIN SYRUP Sun Pharmaceutical Industries Ltd. NUTRILIN SYRUP Alkem Laboratories Ltd. LYPTIN SYRUP Mankind Pharma Ltd. APPETIZER SYRUP Aristo Pharmaceuticals Pvt. Ltd.

Mechanism of Action

The combination works through three distinct mechanisms: 1) Cyproheptadine: Antagonizes histamine H1 and serotonin (5-HT2) receptors in the hypothalamic feeding center, stimulating appetite. Its antiserotonergic effect may reduce the sensation of early satiety. 2) Tricholine Citrate: Acts as a lipotropic agent, promoting hepatic fat metabolism and export (via increased lecithin synthesis). It also has choleretic properties, increasing bile flow, which aids in fat digestion and absorption. 3) Sorbitol: An osmotic laxative that draws water into the intestinal lumen, softening stools and stimulating peristalsis, thereby relieving constipation often associated with poor dietary intake or Cyproheptadine use.