Cyproheptadine (2mg) + Tricholine Citrate (275mg) + Sorbitol (3.575gm) (Medical Monograph)

Overview

A fixed-dose combination therapy primarily used as an appetite stimulant and hepatoprotective agent in the Indian market. Cyproheptadine is a first-generation antihistamine with serotonin-antagonist and appetite-stimulating properties. Tricholine Citrate acts as a lipotropic agent and choleretic, aiding fat metabolism and bile flow. Sorbitol is an osmotic agent and sweetening syrup base that provides a mild laxative effect and improves palatability. This combination is widely prescribed for underweight children and adults, and for supportive care in liver disorders.

The combination works synergistically. Cyproheptadine antagonizes histamine H1 and serotonin (5-HT2) receptors in the hypothalamic feeding center, reducing the sensation of satiety and stimulating appetite. Tricholine Citrate provides choline, a component of phosphatidylcholine, essential for hepatic fat export (as VLDL) and cell membrane integrity, thus preventing fatty infiltration. It also has choleretic action. Sorbitol creates an osmotic gradient in the gut, drawing water into the lumen, softening stools, and relieving constipation often associated with Cyproheptadine. Its sweet taste improves compliance.