crocin pain relief tablet - Caffeine (50mg) + Paracetamol (650mg) medicine

crocin pain relief tablet

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🏭 GlaxoSmithKline Consumer Healthcare 📦 Varies by brand 💊 Allopathy 📅 Updated: Sep 23, 2026
📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Reviewed by
SaathiMed Expert Panel | Sep 23, 2026

What is crocin pain relief tablet used for?

This medicine contains Caffeine (50mg) + Paracetamol (650mg) and is used to treat PAIN ANALGESICS. Paracetamol: Inhibits COX-1 and COX-2 in the CNS, reducing prostaglandin synthesis; Caffeine: Adenos. Always consult your doctor before use.

  • Generic Name: Paracetamol + Caffeine
  • Manufacturer: GlaxoSmithKline Consumer Healthcare
  • Form: Allopathy
  • Pregnancy Category: Category A
  • Prescription Required: Yes
💡 Did You Know? India is the largest provider of generic medicines globally, supplying over 50% of global vaccine demand.

💊 crocin pain relief tablet Uses & Benefits

Mild to moderate pain, fever, headache, menstrual cramps.

Off-label uses: None commonly recognized.

📋 Drug Information

Generic Name(s)Paracetamol + Caffeine
Brand NameAnacin Tablet
ManufacturerGlaxoSmithKline Consumer Healthcare
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassPAIN ANALGESICS
Action ClassAnalgesic and Antipyretic
Route of AdministrationOral
StorageStore at room temperature (20-25°C), protect from moisture.
Shelf LifeAs per manufacturer

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionRapidly and completely absorbed from the gastrointestinal tract.
DistributionDistributed throughout most body tissues; crosses placenta and appears in breast milk.
Protein Binding10-25% for paracetamol; 25-36% for caffeine.
MetabolismParacetamol: Hepatic via conjugation (glucuronidation, sulfation) and CYP450 (minor); Caffeine: Hepatic via CYP1A2.
Half-LifeParacetamol: 1-4 hours; Caffeine: 3-6 hours.
ExcretionParacetamol: Renal (90-100% as metabolites); Caffeine: Renal (as metabolites).
BioavailabilityParacetamol: 60-90%; Caffeine: ~100%.
Onset of ActionParacetamol: 30-60 minutes; Caffeine: 15-45 minutes.
Peak Plasma TimeParacetamol: 0.5-2 hours; Caffeine: 0.5-1 hour.
Duration of ActionParacetamol: 4-6 hours; Caffeine: 3-5 hours.

How It Works

Paracetamol: Inhibits COX-1 and COX-2 in the CNS, reducing prostaglandin synthesis; Caffeine: Adenosine receptor antagonist, enhancing analgesic effect.

Mechanism Steps

1Paracetamol inhibits cyclooxygenase (COX) enzymes in the central nervous system.
2Reduced prostaglandin synthesis leads to decreased pain perception and fever.
3Caffeine blocks adenosine receptors (A1 and A2A) in the brain.
4Adenosine antagonism reduces pain signal transmission and enhances analgesic effect.
5Caffeine also causes mild vasoconstriction and CNS stimulation.

💡 How to Take crocin pain relief tablet

Follow your doctor's prescription exactly.

⚠️ Side Effects of crocin pain relief tablet

✅ Common Side Effects

Nausea
Vomiting
Insomnia
Nervousness
Dizziness

🚨 Serious Side Effects

Hepatotoxicity
Stevens-Johnson syndrome
Anaphylaxis

⚠️ Rare Side Effects

Thrombocytopenia
Agranulocytosis
Pancreatitis

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Warfarin Major Increased INR and bleeding risk with high doses of paracetamol.
Alcohol Major Increased hepatotoxicity risk with chronic heavy use.
Isoniazid Major Increased risk of hepatotoxicity.
Rifampin Major Reduced paracetamol efficacy; increased hepatotoxicity.
Oral contraceptives Moderate Reduced caffeine clearance.
Cimetidine Moderate Increased caffeine levels.
Disulfiram Moderate Reduced caffeine clearance.
Phenytoin Moderate Reduced paracetamol efficacy.
Theophylline Minor Additive CNS stimulation.
Beta-blockers Minor Reduced caffeine clearance.
Quinolones Minor Reduced caffeine clearance.

🚨 Major Interactions

  • Warfarin
  • Alcohol (chronic heavy use)
  • Isoniazid
  • Rifampin

⚡ Moderate Interactions

  • Oral contraceptives
  • Cimetidine
  • Disulfiram
  • Phenytoin

🍷 Alcohol Interaction

Chronic heavy alcohol use increases hepatotoxicity risk.

🛡️ Safety & Warnings

🚫 Contraindications

Hypersensitivity to paracetamol or caffeine; severe hepatic impairment.

🤱 Lactation Safety

Paracetamol is safe in usual doses; caffeine excreted in milk, limit intake.

💊 Overdose Management

Activated charcoal, N-acetylcysteine for paracetamol toxicity; supportive care for caffeine.

⏰ Missed Dose

Take as soon as remembered; skip if near next dose; do not double.

🔄 Substitutes for crocin pain relief tablet

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

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