Clobetasol (0.5mg) + Gentamicin (1mg) + Clioquinol (Iodochlorhydroxyquin) (10mg) + Ketoconazole (20mg) + Tolnaftate (10mg) (Medical Monograph)

Overview

A potent, multi-ingredient topical combination preparation designed for the treatment of severe, complicated, or mixed dermatological infections with significant inflammation. It combines a super-potent corticosteroid (Clobetasol) with broad-spectrum antibacterial (Gentamicin), antifungal (Ketoconazole, Tolnaftate), and antibacterial/antifungal (Clioquinol) agents. This formulation is intended for short-term use in cases where infection and inflammation coexist, such as severe infected eczema, infected psoriasis, or extensive tinea corporis/cruris with secondary bacterial infection and inflammation.

This combination exerts a multifaceted action: 1) Potent anti-inflammatory, immunosuppressive, and antipruritic effects via clobetasol. 2) Bactericidal action against Gram-negative and some Gram-positive bacteria via gentamicin. 3) Broad-spectrum antifungal and antibacterial action via clioquinol (effective against dermatophytes, Candida, and some bacteria). 4) Antifungal action against dermatophytes, yeasts (including Malassezia), and some Gram-positive bacteria via ketoconazole. 5) Specific antifungal action against dermatophytes via tolnaftate.