Choline Salicylate (8.7% w/w) + Cetalkonium Chloride (0.01% w/w) (Medical Monograph)

Overview

A topical analgesic and anti-inflammatory solution primarily used for the relief of mild to moderate pain and inflammation associated with sore throat, pharyngitis, and tonsillitis. Choline Salicylate is a non-steroidal anti-inflammatory drug (NSAID) derivative of salicylic acid, providing local analgesic and anti-inflammatory effects. Cetalkonium Chloride is a quaternary ammonium compound (quat) antiseptic that provides local antibacterial and antifungal activity, helping to reduce microbial load in the oropharyngeal cavity. This combination is formulated as a mouth paint or gargle solution.

Choline Salicylate exerts its local analgesic and anti-inflammatory effects by inhibiting the enzyme cyclooxygenase (COX), both COX-1 and COX-2, at the site of application. This inhibition reduces the synthesis of prostaglandins, which are mediators of pain, inflammation, and fever. Its choline component may enhance local penetration. Cetalkonium Chloride is a cationic surfactant that disrupts microbial cell membranes, leading to leakage of cellular contents and death of bacteria and fungi. It provides a broad-spectrum antiseptic action, reducing secondary infection risk in inflamed tissues.