A fixed-dose combination (FDC) medication primarily used for the symptomatic relief of dry, non-productive cough associated with allergic conditions like the common cold and allergic rhinitis. Chlorpheniramine is a first-generation sedating antihistamine, Dextromethorphan is a centrally-acting non-opioid antitussive, and Menthol provides local soothing and decongestant effects. This combination is widely used in India for its efficacy in suppressing cough and managing associated upper respiratory symptoms.
Adult Dosage: One tablet every 4-6 hours. Maximum: 4 tablets in 24 hours.
Instructions: Take orally with or without food. Swallow whole with a glass of water. Can be taken with food if GI upset occurs. Do not crush or chew (for standard tablets). Advise to avoid driving or operating machinery after dose.
The combination works synergistically: Chlorpheniramine competitively antagonizes histamine at H1-receptors, reducing allergic symptoms like rhinorrhea and sneezing, and has anticholinergic effects that may help dry secretions. Dextromethorphan acts centrally on the cough center in the medulla oblongata, raising the threshold for cough reflex. Menthol activates cold-sensitive TRPM8 receptors in the respiratory tract, providing a cooling sensation, mild local anesthesia, and a perceived relief of congestion.