A fixed-dose combination oral liquid primarily indicated for the symptomatic relief of dry, non-productive cough associated with allergic conditions like the common cold and allergic rhinitis. Chlorpheniramine is a first-generation alkylamine H1-antihistamine providing anti-allergic effects. Dextromethorphan is a centrally-acting non-opioid antitussive that suppresses the cough reflex in the medulla. Menthol provides local soothing, mild local anesthetic, and decongestant effects on the throat and upper respiratory tract mucosa.
Adult Dosage: 10 ml (2 teaspoonfuls) three to four times daily. Maximum: 40 ml per day.
Instructions: To be taken orally. Use the measuring cup or spoon provided. Can be taken with or without food. Taking with food may reduce GI upset. Do not drive or operate machinery after taking.
Chlorpheniramine competitively antagonizes histamine at the H1 receptor, reducing capillary permeability, bronchoconstriction, and itching. Dextromethorphan acts centrally on the cough center in the medulla oblongata, raising the threshold for coughing. It is a non-competitive NMDA receptor antagonist and sigma-1 receptor agonist. Menthol activates cold-sensitive TRPM8 receptors in the oropharyngeal mucosa, producing a cooling sensation, mild local anesthesia, and a perceived relief of throat irritation.