Chlorpheniramine Maleate (2mg) + Paracetamol (500mg) + Phenylephrine (5mg) (Medical Monograph)

Overview

A fixed-dose combination (FDC) medication widely used in India for symptomatic relief of common cold, allergic rhinitis, and sinusitis. It combines an antihistamine (Chlorpheniramine), an analgesic-antipyretic (Paracetamol), and a decongestant (Phenylephrine) to provide comprehensive relief from fever, pain, nasal congestion, sneezing, and runny nose.

This combination works synergistically. Chlorpheniramine competitively antagonizes histamine at H1 receptors, reducing allergic symptoms. Paracetamol inhibits cyclooxygenase (COX) enzymes, particularly in the CNS, reducing prostaglandin synthesis for analgesia and antipyresis. Phenylephrine is a selective alpha-1 adrenergic agonist causing vasoconstriction in nasal mucosa, reducing edema and congestion.