A fixed-dose combination (FDC) medication primarily used for the symptomatic relief of dry, non-productive cough associated with allergic conditions like allergic rhinitis and the common cold. Chlorpheniramine is a first-generation sedating antihistamine, Dextromethorphan is a centrally-acting non-opioid antitussive, and Menthol provides local soothing and decongestant effects. This combination is widely used in India for its efficacy in suppressing cough and managing associated upper respiratory symptoms.
Adult Dosage: One tablet every 4-6 hours. Maximum: 4 tablets in 24 hours.
Instructions: Take orally with or without food. Swallow whole with a glass of water. Do not crush or chew. Can be taken at bedtime to utilize sedative effect for cough disturbing sleep. Maintain adequate hydration.
Chlorpheniramine competitively antagonizes histamine at the H1 receptor, reducing allergic symptoms like rhinorrhea and sneezing, and has anticholinergic effects contributing to cough suppression and sedation. Dextromethorphan acts centrally on the cough center in the medulla oblongata, raising the threshold for coughing. It is a non-competitive NMDA receptor antagonist and sigma-1 receptor agonist. Menthol activates cold-sensitive TRPM8 receptors in the respiratory tract, providing a cooling sensation, mild local anesthesia, and perceived relief of throat irritation and nasal congestion.