Chloramphenicol (NA) + Clotrimazole (NA) + Beclometasone (NA) (Medical Monograph)

Overview

A fixed-dose combination topical preparation containing an antibiotic (Chloramphenicol), an antifungal (Clotrimazole), and a corticosteroid (Beclometasone). It is primarily used for the treatment of mixed bacterial and fungal skin infections complicated by inflammation. This combination addresses infection, inflammation, and pruritus simultaneously, commonly used for conditions like infected eczema, otitis externa, and intertrigo in the Indian clinical setting.

This combination exerts a triple action: Chloramphenicol inhibits bacterial protein synthesis, Clotrimazole disrupts fungal cell membrane integrity, and Beclometasone suppresses inflammatory and immune responses.