Chloramphenicol (5% w/v) + Clotrimazole (1% w/v) + Beclometasone (0.025% w/v) (Medical Monograph)

Overview

A fixed-dose combination topical preparation containing an antibiotic (Chloramphenicol), an antifungal (Clotrimazole), and a corticosteroid (Beclometasone). It is primarily indicated for the treatment of mixed bacterial and fungal infections of the skin, particularly when accompanied by inflammation and pruritus. This combination provides broad-spectrum antimicrobial coverage along with anti-inflammatory and antipruritic effects, making it a common choice for infected dermatoses in the Indian clinical setting.

This combination exerts a triple action: Chloramphenicol inhibits bacterial protein synthesis, Clotrimazole disrupts fungal cell membrane integrity, and Beclometasone suppresses inflammation, immune responses, and pruritus.