Bromhexine (4mg) + Guaifenesin (50mg) + Menthol (2.5mg) + Terbutaline (1.25mg)

🩺 Quick Overview

A fixed-dose combination (FDC) expectorant, mucolytic, and bronchodilator syrup/tablet primarily used for symptomatic relief in productive cough associated with bronchospasm in conditions like acute and chronic bronchitis, asthma, and COPD. Bromhexine thins viscous sputum, guaifenesin increases respiratory tract fluid, menthol provides soothing relief, and terbutaline relieves bronchoconstriction.

Medical Uses

  • Symptomatic treatment of productive cough associated with bronchospasm in Acute Bronchitis
  • Chronic Bronchitis
  • Bronchial Asthma (as adjunct therapy for relief of bronchospasm)

Side Effects

  • Nausea
  • Gastric irritation
  • Headache
  • Dizziness
  • Mild tremor (due to terbutaline)
  • Palpitations
  • Mild sweating
  • Taste disturbance (menthol)

💊 Dosage & Administration

Adult Dosage: 10 ml (2 teaspoonfuls) of syrup or 1 tablet, three to four times daily. Maximum: 4 doses in 24 hours.

Instructions: Syrup: To be taken orally, preferably after meals with a full glass of water to aid expectoration. Tablet: Swallow whole with water. Do not crush or chew. Maintain adequate hydration.

🏭 Available Brands in India

Ascoril Expectorant Glenmark Pharmaceuticals Ltd. Kofarest Expectorant Macleods Pharmaceuticals Ltd. Bromhexine-GF-M-T Syrup Cipla Ltd. Tusq-X Expectorant Sun Pharmaceutical Industries Ltd. Chericof Expectorant Aristo Pharmaceuticals Pvt. Ltd.

Mechanism of Action

Combined action: Bromhexine depolymerizes mucopolysaccharide fibers in sputum, reducing viscosity. Guaifenesin stimulates gastric vagal receptors, reflexively increasing respiratory tract fluid secretion, lubricating airways. Menthol acts as a mild local anesthetic and counter-irritant, providing a cooling sensation and soothing cough reflex. Terbutaline selectively stimulates beta-2 adrenergic receptors in bronchial smooth muscle, causing relaxation and bronchodilation.