Amicline Plus Tablet: Comprehensive Guide to Uses, Dosage, and Safety
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Blood in stool or vomit
- Severe abdominal pain
- Yellowing of skin or eyes
- Dark urine
- Numbness or tingling in hands or feet
- Unusual bleeding or bruising
- Severe allergic reaction (rash, swelling, difficulty breathing)
- Seizures
If experiencing severe symptoms, call emergency services immediately.
What is amicline plus tablet used for?
This medicine is a combination of Ornidazole and Diloxanide used to treat intestinal amoebiasis and other protozoal infections. It works by killing parasites in both the gut tissue and lumen. Take it exactly as prescribed, avoid alcohol, and complete the full course.
- Generic Name: Ornidazole + Diloxanide
- Manufacturer: Franco-Indian Pharmaceuticals Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 amicline plus tablet के बारे में (Hindi Summary)
उपयोग: यह दवा ओर्निडाजोल और डाइलोक्सानाइड का संयोजन है, जिसका उपयोग आंतों के अमीबियासिस (अमीबिक पेचिश) और अन्य प्रोटोजोआ संक्रमणों के इलाज के लिए किया जाता है। यह आंतों में परजीवियों को मारती है और दस्त, पेट दर्द, और बुखार जैसे लक्षणों से राहत देती है।
साइड इफेक्ट्स: आम दुष्प्रभावों में मतली, उल्टी, पेट में असुविधा, मुंह में धातु जैसा स्वाद, सिरदर्द और चक्कर आना शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन एलर्जी, रक्त विकार, और यकृत विषाक्तता हो सकती है। कोई भी असामान्य लक्षण दिखने पर तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के निर्देशानुसार ही लें। उपचार के दौरान और अंतिम खुराक के 48 घंटे बाद तक शराब का सेवन बिल्कुल न करें। यकृत या गुर्दे की बीमारी हो तो डॉक्टर को बताएं। पूरा कोर्स पूरा करें चाहे आप बेहतर महसूस करें।
💊 amicline plus tablet Uses & Benefits
[{"condition":"Intestinal amoebiasis","description":"Treatment of amoebic dysentery and non-dysenteric intestinal amoebiasis caused by Entamoeba histolytica.","evidence":"Well-established"},{"condition":"Giardiasis","description":"Treatment of giardiasis caused by Giardia lamblia, especially when a luminal agent is needed.","evidence":"Moderate"},{"condition":"Trichomoniasis","description":"Treatment of trichomoniasis caused by Trichomonas vaginalis, often in combination with other agents.","evidence":"Moderate"},{"condition":"Amoebic liver abscess","description":"Adjunct treatment for amoebic liver abscess after tissue amoebicide therapy.","evidence":"Limited"}]
Off-label uses: [{"condition":"Bacterial vaginosis","description":"Sometimes used off-label for bacterial vaginosis due to anaerobic coverage.","evidence":"Limited"},{"condition":"Crohn's disease","description":"Rarely used off-label for perianal fistulizing Crohn's disease based on small studies.","evidence":"Limited"}]
Primary treatment for: Intestinal amoebiasis
Also treats: Giardiasis, Trichomoniasis, Amoebic liver abscess
📋 Drug Information
| Generic Name(s) | Ornidazole + Diloxanide |
| Brand Name | Amicline Plus Tablet |
| Manufacturer | Franco-Indian Pharmaceuticals Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI INFECTIVES |
| Action Class | Antiprotozoal and Amebicide |
| Route of Administration | Oral |
| Storage | Store at room temperature (15-30°C) in a dry place, away from direct sunlight. Keep in the original container. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
Ornidazole is a nitroimidazole derivative that enters susceptible protozoal cells and undergoes reductive activation by ferredoxin-like electron transport proteins. The reduced nitro group forms reactive intermediates that bind to DNA, causing strand breakage and inhibition of nucleic acid synthesis, which leads to cell death. Diloxanide is a luminal amoebicide that acts by inhibiting protein synthesis in Entamoeba histolytica trophozoites residing in the intestinal lumen. It is poorly absorbed from the gastrointestinal tract, allowing high concentrations in the gut to eliminate luminal parasites. Together, they provide both tissue and luminal amoebicidal activity.
Mechanism Steps
💡 How to Take amicline plus tablet
Strength: Each tablet contains Ornidazole 250 mg and Diloxanide 375 mg.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is one tablet taken orally two to three times daily, depending on the severity of the infection and the treating doctor's judgment. The duration of treatment typically ranges from 5 to 10 days for intestinal amoebiasis. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not self-medicate or adjust the dose without medical advice. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may have reduced liver and kidney function, which can affect drug clearance. Dose adjustment may be necessary. Use with caution and monitor for side effects. Consult a doctor for appropriate dosing. |
| Renal Impairment | In patients with severe renal impairment (creatinine clearance less than 30 mL/min), dose reduction may be necessary. Monitor for side effects. Consult a doctor for appropriate dosing. |
| Hepatic Impairment | In patients with severe hepatic impairment, dose reduction or avoidance may be necessary. Monitor liver function. Consult a doctor for appropriate dosing. |
| Maximum Daily Dose | The maximum recommended daily dose is 750 mg of ornidazole and 1125 mg of diloxanide (three tablets per day). Do not exceed the prescribed dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of amicline plus tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Alcohol | Major | |
| Lithium | Major | |
| Phenytoin | Moderate | |
| Cimetidine | Moderate | |
| Fluconazole | Moderate | |
| Antacids | Minor |
🚨 Major Interactions
- Warfarin
- Alcohol
- Lithium
⚡ Moderate Interactions
- Phenytoin
- Cimetidine
- Fluconazole
🍷 Alcohol Interaction
Alcohol must be strictly avoided while taking this medicine and for at least 48 hours after the last dose. Combining alcohol with ornidazole can cause a disulfiram-like reaction characterized by severe nausea, vomiting, flushing, headache, and rapid heartbeat. This reaction can be dangerous and requires immediate medical attention if it occurs.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to ornidazole, diloxanide, or other nitroimidazoles.","First trimester of pregnancy.","Severe hepatic impairment.","Use of alcohol during treatment and for 48 hours after.","Breastfeeding without medical advice."]
⚠️ Warnings & Precautions
["Avoid alcohol during treatment and for 48 hours after the last dose.","Use with caution in patients with liver disease; dose adjustment may be needed.","Use with caution in patients with kidney disease; dose adjustment may be needed.","May cause dizziness; avoid driving or operating machinery until you know how it affects you.","May cause peripheral neuropathy with prolonged use; report numbness or tingling.","May cause blood disorders; report unusual bleeding or bruising.","Use effective contraception during treatment if of childbearing age.","Do not breastfeed while taking this medicine without consulting your doctor.","Complete the full course as prescribed to prevent relapse and resistance."]
🤱 Lactation Safety
Ornidazole is excreted in breast milk. Due to the potential for serious adverse reactions in nursing infants, a decision should be made whether to discontinue nursing or discontinue the drug, taking into account the importance of the drug to the mother. Consult your doctor.
💊 Overdose Management
Overdose may cause nausea, vomiting, dizziness, and headache. In case of overdose, seek immediate medical attention. Treatment is supportive and symptomatic. There is no specific antidote. Gastric lavage may be considered if ingestion is recent. Monitor vital signs and provide supportive care.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose to catch up.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not share it with others. Avoid alcohol completely during treatment and for at least 48 hours after the last dose, as it can cause a disulfiram-like reaction with severe nausea and vomiting. Inform your doctor if you have liver disease, kidney disease, or any blood disorder. Use effective contraception during treatment if you are of childbearing age. Do not breastfeed while taking this medicine without consulting your doctor. Complete the full course even if you feel better to prevent recurrence.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more sensitive to the side effects of this medicine, especially dizziness and neurological effects. Dose adjustment may be needed based on liver and kidney function. Regular monitoring is advised.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy, consult your doctor before taking this medicine. It is not recommended during the first trimester. Use effective contraception during treatment. Discuss the risks and benefits with your doctor.
🏥 Post-Surgery Considerations
If you have recently undergone surgery, inform your surgeon that you are taking this medicine. It may interact with other medications used during surgery. Your doctor will decide if it is safe to continue.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine before any dental procedure. It may interact with medications used during dental work. Your dentist may advise you to stop temporarily.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
If you experience dizziness or fatigue, avoid strenuous exercise until you feel better. Light activity is generally safe, but listen to your body and rest when needed.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or fatigue in some people. Avoid driving or operating heavy machinery until you know how it affects you. Most people can continue their daily activities with caution. If you have severe diarrhea, rest and hydration are important.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor, even if you feel better. Stopping early can lead to relapse and resistance. If you experience severe side effects, contact your doctor immediately for advice.
📅 Long-Term Use Effects
Long-term use of this medicine is not recommended unless prescribed by a doctor. Prolonged use may increase the risk of peripheral neuropathy, blood disorders, and liver toxicity. Regular monitoring of liver function and blood counts may be required if extended treatment is necessary. Always follow your doctor's advice regarding duration of treatment.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Alternative combination for intestinal amoebiasis.
Evidence: Well-establishedAlternative with longer half-life, shorter course.
Evidence: ModerateLuminal amoebicide for mild intestinal amoebiasis.
Evidence: Moderate💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no known interactions between this medicine and vaccines. However, if you are due for any vaccine, inform your doctor that you are taking this medicine.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
Carry this medicine in its original packaging with a copy of your prescription. Store at room temperature and protect from direct sunlight. If traveling across time zones, adjust dosing intervals as advised by your doctor. Check customs regulations for carrying prescription medicines. Always carry enough supply for your entire trip.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: You may start feeling better within 2-3 days, but it is important to complete the full course as prescribed.
A: Yes, taking it with food helps reduce stomach upset.
A: Take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose.
A: No, alcohol can cause a severe reaction. Avoid alcohol completely during treatment and for 48 hours after the last dose.
🤔 Common Patient Concerns
🔄 Substitutes for amicline plus tablet
View AllAlternative brands with exact same active ingredient:
-
metrogyl compound plus tabletJ B Chemicals and Pharmaceuticals Ltd ₹125.33 12.2% COSTLIER
-
entrogyl-oz tabletProfic Organic Ltd ₹126.50 13.2% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can cure any type of diarrhea.
Fact: This medicine is specifically for protozoal infections like amoebiasis. It is not effective for viral or bacterial diarrhea. - Myth: You can stop taking this medicine once you feel better.
Fact: You must complete the full course to prevent relapse and resistance. - Myth: It is safe to drink alcohol while taking this medicine.
Fact: Alcohol can cause a severe disulfiram-like reaction. Avoid completely.
🔄 Alternative Options
Generic Alternatives
- Ornidazole + Diloxanide combination generics
Brand Alternatives
- Amicline Plus
- Diloxanide Ornidazole
- Ornidazole Diloxanide