A fixed-dose combination topical preparation containing a corticosteroid (Beclometasone), an antifungal (Clotrimazole), and an aminoglycoside antibiotic (Gentamicin). It is primarily indicated for the treatment of mixed dermatological infections where inflammation, fungal overgrowth, and bacterial infection coexist, commonly seen in conditions like infected eczema, intertrigo, and infected dermatophytosis in the Indian climatic context.
Adult: Apply a thin film to the affected area 2 to 3 times daily, or as directed by the physician. Duration should not exceed 4 weeks continuously.
Note: Wash and dry the affected area thoroughly. Apply a thin layer and rub gently. Wash hands after application unless hands are the treated area. Do not cover with occlusive dressings unless advised. Do not use in or near the eyes.
This combination exerts a triple action: Beclometasone provides potent anti-inflammatory, anti-pruritic, and vasoconstrictive effects; Clotrimazole inhibits the synthesis of ergosterol, a critical component of fungal cell membranes, leading to increased permeability and cell death; Gentamicin is bactericidal, inhibiting bacterial protein synthesis by binding to the 30S ribosomal subunit.
Pregnancy: Category C (US FDA). Topical corticosteroids, clotrimazole, and gentamicin can be absorbed in small amounts. Use only if clearly needed and potential benefit justifies potential risk to the fetus. Avoid large amounts or long-term use.
Driving: No effect expected from topical use.
| Other Topical Corticosteroids | Additive risk of local and systemic side effects. | Major |
| Other Aminoglycosides (e.g., systemic Amikacin, Tobramycin) | Increased risk of ototoxicity and nephrotoxicity. | Major |
| Loop Diuretics (e.g., Furosemide) | Potentiates the ototoxic risk of Gentamicin. | Moderate |
| Warfarin | Clotrimazole (if systemically absorbed) may inhibit its metabolism, increasing INR and bleeding risk. | Moderate |
Same composition (Beclometasone (0.025% w/w) + Clotrimazole (1% w/w) + Gentamicin (0.1% w/w)), different brands: