Zinc Oxide 8.5% w/w is a topical dermatological agent primarily used as a mild astringent, skin protectant, and soothing agent. It forms a protective barrier on the skin, absorbing moisture and providing a drying effect. It is minimally absorbed systemically when applied to intact skin, making it a safe and widely used OTC product in India for various minor skin conditions.
Adult: Apply a thin layer to the affected area 3 to 4 times daily, or as directed by a physician. More frequent application (e.g., with each diaper change) may be used for diaper rash.
Note: Clean and dry the affected area thoroughly before application. Apply a thin, even layer. Can be covered with a dressing if needed, but for diaper rash, allow the area to air-dry briefly before applying diaper. For external use only. Avoid contact with eyes and mucous membranes.
Zinc Oxide exerts its effects through physical and mild chemical actions. It forms an occlusive, hydrophobic layer on the skin surface, which protects underlying tissue from moisture, friction, and irritants (urine, feces). It has mild astringent properties, causing slight contraction of the skin and drying of exudative areas. It also exhibits weak antiseptic properties and may have a soothing, cooling effect.
Pregnancy: Category A (US FDA). Topical Zinc Oxide is considered safe during pregnancy as systemic absorption is negligible. Widely used for pregnancy-related hemorrhoids and skin changes.
Driving: No effect.
| Topical Corticosteroids (e.g., Hydrocortisone, Mometasone) | Zinc Oxide base may alter the absorption of the steroid. Apply steroid first, wait for absorption, then apply Zinc Oxide as a barrier if needed. | Moderate |
| Topical Antibiotics (e.g., Neomycin, Fusidic Acid) | The occlusive barrier may theoretically reduce penetration of the antibiotic. Apply antibiotic first, then Zinc Oxide. | Mild |
Same composition (Zinc Oxide (8.5% w/w)), different brands: