A fixed-dose combination antitussive and antihistaminic syrup used for the symptomatic relief of dry, non-productive cough associated with allergic conditions like allergic rhinitis or the common cold. Chlorpheniramine is a first-generation alkylamine H1-antihistamine, Codeine is a centrally-acting opioid antitussive, and Menthol provides local soothing and decongestant effects.
Adult: 10 ml (2 teaspoonfuls) three to four times daily. Maximum: 40 ml per day.
Note: To be taken orally. Use the measuring cup/spoon provided. Can be taken with or without food. Do not drive or operate machinery after intake. Avoid alcohol.
The combination acts synergistically. Chlorpheniramine antagonizes histamine at H1 receptors, reducing allergic symptoms and providing mild sedative effects. Codeine, an opioid agonist, suppresses the cough reflex by direct action on the cough center in the medulla oblongata. Menthol acts as a topical cooling/soothing agent on irritated pharyngeal mucosa, providing symptomatic relief and a sensation of easier breathing.
Pregnancy: Category C (US FDA). Avoid, especially in third trimester (risk of neonatal withdrawal syndrome and respiratory depression in newborn). Use only if potential benefit justifies potential fetal risk.
Driving: IMPAIRMENT ALERT: May cause drowsiness, dizziness, and blurred vision. Patients should not drive or operate heavy machinery until their response is known.
| Alcohol, Benzodiazepines, Barbiturates | Potentiated CNS and respiratory depression | Major |
| MAO Inhibitors (Phenelzine, Tranylcypromine) | Risk of hypertensive crisis, hyperpyrexia | Major |
| Other Opioids (Morphine, Tramadol) | Additive CNS depression, respiratory depression, constipation | Major |
| SSRIs/SNRIs (Fluoxetine, Paroxetine), TCAs | Increased codeine effect (CYP2D6 inhibition), risk of serotonin syndrome | Moderate |
| CNS Depressants (Antipsychotics, Skeletal Muscle Relaxants) | Increased sedation and respiratory depression | Moderate |
| Anticholinergics (Atropine, Oxybutynin, TCAs) | Potentiated anticholinergic side effects (dry mouth, urinary retention, confusion) | Moderate |
| Rifampicin, Carbamazepine, Phenytoin | Reduced codeine efficacy (CYP3A4 induction) | Moderate |