A nutraceutical/ethical pharmaceutical combination product containing a micronized form of the adrenal prohormone Dehydroepiandrosterone (DHEA) and the biologically active form of folate, L-Methylfolate. DHEA serves as a precursor to androgens and estrogens, while L-Methylfolate is critical for methylation processes and neurotransmitter synthesis. This combination is primarily used to address age-related decline in DHEA levels and support neurological and cardiovascular health, particularly in individuals with folate metabolism impairments.
Adult: One tablet daily, preferably in the morning with food. Dose of DHEA should be individualized based on serum DHEA-S levels. 75mg is a common supplemental dose.
Note: Administer orally with a meal to enhance absorption and reduce potential gastrointestinal upset. Swallow whole with a glass of water. Do not crush or chew. Avoid taking late in the evening as DHEA may cause insomnia in some individuals.
DHEA is an endogenous steroid hormone precursor produced by the adrenal glands. It is converted peripherally into androgens (like testosterone) and estrogens (like estradiol), exerting its effects through these downstream hormones. It also has weak androgenic activity itself. L-Methylfolate (5-MTHF) is the biologically active form of folate that crosses the blood-brain barrier. It is a critical cofactor in the synthesis of neurotransmitters (serotonin, dopamine, norepinephrine) via the methylation cycle and in the conversion of homocysteine to methionine.
Pregnancy: CONTRANDICATED. DHEA is a hormone precursor with androgenic effects, posing a risk of virilization of a female fetus. Folate requirements are high in pregnancy, but should be met with standard prenatal supplements (Folic Acid or L-Methylfolate as per obstetrician's advice) without DHEA.
Driving: Unlikely to affect driving ability. However, patients should be cautioned about potential dizziness, fatigue, or mood changes initially that could impair skills.
| Warfarin and other Anticoagulants | L-Methylfolate may theoretically affect coagulation; DHEA may alter protein binding. Monitor INR closely. | Moderate |
| Antiepileptic Drugs (Phenytoin, Phenobarbital, Valproate) | Folate can reduce serum levels of phenytoin/phenobarbital. DHEA may lower seizure threshold. Monitor drug levels and seizure control. | Major |
| Tamoxifen, Aromatase Inhibitors | DHEA may counteract the estrogen-suppressing effects. Avoid concurrent use. | Major |
| Corticosteroids | May suppress endogenous DHEA production. Interaction significance unclear. | Moderate |
| Testosterone, Estrogen HRT | Additive hormonal effects. Risk of excessive androgenic/estrogenic side effects. Use with extreme caution and monitoring. | Major |
| Methotrexate | Folate can reduce toxicity but also efficacy of methotrexate for cancer. For rheumatoid arthritis/psoriasis, L-Methylfolate is often used to reduce side effects under supervision. Do not self-administer. | Major |
| Metformin | Can lower vitamin B12 and folate levels. L-Methylfolate supplementation may be beneficial, but monitor B12. | Moderate |
| SSRIs/SNRIs (e.g., Sertraline, Escitalopram) | L-Methylfolate may augment antidepressant effect. DHEA's mood effects may be additive. Monitor for serotonin syndrome symptoms (rare). | Moderate |
Same composition (Dehydroepiandrosterone (Micronized) (75mg) + L-Methyl Folate (500mcg)), different brands: