Vitamin A (25000IU) is a high-potency formulation of retinol, a fat-soluble vitamin essential for vision, immune function, cellular differentiation, and epithelial integrity. In the Indian context, it is primarily used for the treatment of severe deficiency states, particularly in high-risk populations such as pregnant women (in specific deficiency scenarios), children with xerophthalmia, and individuals with malabsorption syndromes. The 25000IU strength is a therapeutic dose and is not intended for routine supplementation or prophylactic use.
Adult: For severe deficiency: 100,000 to 200,000 IU orally as a single dose, or 50,000 IU daily for 2 weeks. Maintenance: 10,000 to 20,000 IU daily for 2 months. NOTE: 25000IU capsule is often used as part of such regimens. Dosing must be individualized based on severity.
Note: Take orally, immediately after a meal containing dietary fat (e.g., milk, nuts, oil) to maximize absorption. Swallow the soft gelatin capsule whole with water. Do not crush or chew.
Vitamin A (retinol) is a prohormone for active metabolites retinal and retinoic acid. Retinal is essential for the visual cycle in retinal rod and cone cells, forming rhodopsin. Retinoic acid acts as a ligand for nuclear retinoic acid receptors (RARs and RXRs), which function as transcription factors regulating the expression of genes involved in cellular proliferation, differentiation, and apoptosis, particularly in epithelial tissues.
Pregnancy: CATEGORY X. High-dose Vitamin A (≥10,000 IU/day) is teratogenic, causing retinoid embryopathy (craniofacial, cardiac, thymic, CNS abnormalities). Absolute contraindication at 25000IU dose. In deficiency, treatment should be under strict specialist supervision with much lower doses.
Driving: May cause dizziness, blurred vision, or headache. Caution advised until patient's response is known.
| Isotretinoin, Acitretin | Additive toxic effects, dramatically increased risk of hypervitaminosis A and teratogenicity. | Major |
| Oral Contraceptives | May increase plasma levels of Vitamin A. Clinical significance uncertain. | Moderate |
| Cholestyramine, Mineral Oil, Orlistat | Reduced absorption of fat-soluble Vitamin A. | Moderate |
| Warfarin | Vitamin A may potentiate anticoagulant effect, increasing INR and bleeding risk. | Major |
| Tetracycline antibiotics | Increased risk of pseudotumor cerebri when combined with high-dose Vitamin A. | Major |
Same composition (Vitamin A (25000IU)), different brands: