A fixed-dose combination of essential electrolyte salts, Magnesium Citrate and Potassium Citrate, primarily used for the prevention and treatment of hypomagnesemia and hypokalemia, and as an alkalinizing agent in conditions like renal tubular acidosis and uric acid/calcium oxalate nephrolithiasis. It replenishes intracellular magnesium and potassium ions while increasing urinary pH and citrate excretion.
Adult: 1-2 tablets twice or thrice daily, or as directed by the physician. Typical dose for stone prophylaxis: 1 tablet TID with meals. For hypokalemia/hypomagnesemia: Dose titrated based on serum levels.
Note: Take with or immediately after a meal with a full glass of water (200-250 mL). Do NOT crush, chew, or suck the tablet. Swallow whole to avoid local irritation of mouth, esophagus, and stomach. Maintain adequate fluid intake (2.5-3 L/day) unless contraindicated.
The combination works via two primary mechanisms: 1) Replenishment of intracellular cations (Mg2+ and K+), and 2) Systemic and urinary alkalinization. After absorption, citrate is metabolized to bicarbonate, raising blood and urinary pH. This increased pH promotes the dissociation of citric acid into citrate ions, which chelate calcium in the urine, inhibiting the crystallization of calcium oxalate and calcium phosphate. Alkaline urine also increases the solubility of uric acid. Magnesium directly inhibits calcium oxalate crystal growth and aggregation in urine.
Pregnancy: Category C (US FDA). Use only if clearly needed. Magnesium and potassium are essential nutrients, but high-dose supplementation requires monitoring. Benefits may outweigh risks in treating pregnancy-related hypomagnesemia or for stone prophylaxis in susceptible women.
Driving: Unlikely to affect ability. However, be cautious if experiencing side effects like dizziness, lethargy, or muscle weakness.
| Potassium-Sparing Diuretics (Spironolactone, Amiloride) | Additive risk of severe hyperkalemia | Major |
| ACE Inhibitors (Ramipril, Enalapril) / ARBs (Losartan, Telmisartan) | Increased risk of hyperkalemia | Major |
| NSAIDs (Ibuprofen, Diclofenac) | May reduce renal function, increasing risk of hyperkalemia | Moderate |
| Digoxin | Hypomagnesemia and hypokalemia potentiate digoxin toxicity. This combination corrects that, but rapid over-correction can alter digoxin effect. | Moderate |
| Quinolone Antibiotics (Ciprofloxacin, Levofloxacin), Tetracyclines, Bisphosphonates (Alendronate) | Magnesium can form insoluble complexes, drastically reducing absorption of these drugs. Separate administration by at least 2-4 hours. | Major |
| Anticholinergics / Opioids | May increase risk of GI mucosal injury by delaying tablet transit. | Moderate |
Same composition (Magnesium Citrate (375mg) + Potassium Citrate (1100mg)), different brands: