Tricholine Citrate is a choline-containing compound used primarily as a lipotropic agent and hepatoprotective. It acts as a source of choline, an essential component of phospholipids (like phosphatidylcholine) vital for hepatic fat metabolism. In the Indian context, it is widely prescribed for fatty liver disease, hepatitis, and alcohol-related liver disorders, often as an adjunct to dietary and lifestyle modifications.
Adult: 10-15 ml (500-750 mg Tricholine Citrate) orally, two to three times daily, after meals. Commonly: 10 ml (500 mg) TID.
Note: To be taken orally, undiluted or mixed with a small amount of water, after meals. Use the measuring cup or spoon provided. Do not mix with hot liquids.
Tricholine Citrate provides choline, which is a key methyl donor and an essential component of phosphatidylcholine. Phosphatidylcholine is critical for the synthesis of very-low-density lipoproteins (VLDL), which are necessary for the export of triglycerides from the liver. In choline deficiency, fat accumulates in hepatocytes, leading to steatosis. By replenishing choline stores, it promotes hepatic fat mobilization and export, reducing steatosis. It may also stabilize hepatocyte membranes and exert mild antioxidant effects.
Pregnancy: Category N (Not classified by US FDA). Animal reproduction studies not available. Use only if clearly needed and potential benefit justifies potential risk. Choline is an essential nutrient during pregnancy.
Driving: Unlikely to affect driving ability. However, if dizziness occurs, caution is advised.
| Anticholinergic drugs (e.g., Atropine, Oxybutynin, Tricyclic Antidepressants) | Theoretical antagonism of effects; Tricholine is a choline source/precursor to acetylcholine. | Moderate |
| Cholinesterase Inhibitors (e.g., Donepezil, Rivastigmine) | Additive cholinergic effects, potentially increasing side effects like bradycardia, diarrhea, nausea. | Moderate |
| Methotrexate | Choline may help reduce hepatotoxicity associated with methotrexate; potential beneficial interaction. | Minor |
| Levodopa | Large doses of choline may reduce efficacy of Levodopa by increasing acetylcholine levels, potentially worsening Parkinsonian symptoms. | Moderate |
Same composition (Tricholine Citrate (500mg/10ml)), different brands: