A topical combination product containing Benzyl Nicotinate, a vasodilator, and Heparin, an anticoagulant and anti-inflammatory agent. It is primarily used in the Indian market for the symptomatic relief of superficial thrombophlebitis, hematomas, and localized inflammation. The combination works synergistically to improve local blood flow, reduce clot extension, and alleviate pain and swelling.
Adult: Apply a thin layer of gel/cream (approx. 3-5 cm) to the affected area 2-3 times daily. Gently rub in.
Note: 1. Wash and dry hands and affected area. 2. Apply a small amount and gently massage until absorbed. 3. Wash hands after application. 4. Do not cover with occlusive dressings unless advised. 5. Avoid contact with eyes, mouth, nose, and genital mucosa.
The combination exerts a dual mechanism: Benzyl Nicotinate is hydrolyzed at the site of application, releasing nicotinic acid which acts as a direct vasodilator, increasing local blood flow (hyperemia). This improves oxygen and nutrient supply, aids in the resolution of inflammation, and may enhance the penetration of heparin. Heparin binds to Antithrombin III, potentiating its inhibition of coagulation factors (primarily IIa and Xa), preventing further thrombus formation. It also possesses anti-inflammatory properties by binding to and neutralizing inflammatory mediators, inhibiting leukocyte migration, and promoting tissue repair.
Pregnancy: Category C (US FDA). No well-controlled studies. Use only if potential benefit justifies potential risk to the fetus. Minimal systemic absorption reduces risk.
Driving: No effect. Localized warmth/itching is unlikely to impair ability.
| Oral Anticoagulants (Warfarin, Acenocoumarol) | Potential increased risk of bleeding if heparin is systemically absorbed through broken skin. | Moderate |
| Anti-platelet Drugs (Aspirin, Clopidogrel) | Additive risk of local or systemic bleeding. | Moderate |
| NSAIDs (Topical or Oral like Ibuprofen, Diclofenac) | Increased anti-inflammatory effect; potential for additive bleeding risk. | Mild |
| Other Topical Medications | May alter absorption of either agent. Apply at different times. | Mild |
Same composition (Benzyl Nicotinate (2mg) + Heparin (50IU)), different brands: