A sterile, preservative-free, topical ophthalmic solution combining two demulcent and lubricating agents. It is primarily used as an artificial tear substitute to relieve symptoms of dry eye disease (DED) by mimicking the properties of natural tears, providing lubrication, hydration, and protection to the ocular surface. The formulation is isotonic and has a pH compatible with the eye.
Adult: One or two drops in the affected eye(s) as needed, typically 4 to 6 times daily or as directed by a physician. Can be used more frequently in severe cases.
Note: 1. Wash hands before use. 2. Tilt head back. 3. Gently pull down lower eyelid to form a pouch. 4. Instill the drop(s) into the pouch without touching the dropper tip to the eye, eyelid, or any surface. 5. Close eyes gently for 1-2 minutes. Apply gentle pressure to the inner corner of the eye (nasolacrimal occlusion) to minimize systemic drainage. 6. For single-dose vials: use immediately after opening. Discard the vial after use, even if solution remains. Do not store for later use.
The combination acts synergistically to lubricate, protect, and hydrate the ocular surface. Polyethylene Glycol (PEG) 400 is a high-molecular-weight polymer that forms a hydrophilic film over the cornea, prolonging tear film breakup time (TBUT) and providing sustained lubrication. Propylene Glycol is a humectant and demulcent that binds water, helps stabilize the tear film lipid layer, and promotes epithelial healing.
Pregnancy: Category C (US FDA). No adequate and well-controlled studies in pregnant women. Polyethylene glycol and propylene glycol are commonly used excipients. Use only if clearly needed and potential benefit justifies potential risk to the fetus. Topical ocular use with minimal systemic absorption presents low risk.
Driving: May cause transient blurring of vision after instillation. Patients should not drive or operate machinery until vision clears, which usually takes a few minutes.
| Other topical ophthalmic medications | May dilute other eye drops if instilled simultaneously, reducing their efficacy. | Moderate |
| Eye drops containing preservatives (e.g., Benzalkonium Chloride) | This preservative-free formulation is often recommended to avoid the toxic effects of preservatives. Using preserved drops concurrently may negate this benefit. | Mild |