A fixed-dose combination (FDC) of water-soluble vitamins used for the prevention and treatment of nutritional deficiencies, particularly in high-risk populations. It combines Ascorbic Acid (Vitamin C), Cyanocobalamin (Vitamin B12), Folic Acid, and Niacinamide (Vitamin B3). This formulation is designed to address multiple micronutrient deficiencies commonly seen in the Indian context, such as in pregnant women, the elderly, and individuals with poor dietary intake or malabsorption syndromes. The doses are tailored to meet or exceed the Recommended Dietary Allowance (RDA) for Indian adults.
Adult: One tablet daily, or as directed by the physician. Usually taken after a meal.
Note: Administer orally with a glass of water, preferably after a meal to enhance tolerance and absorption (especially for B12). Do not crush or chew unless specified. Can be taken at any time of the day.
Each component acts as a cofactor or coenzyme in essential metabolic pathways. Vitamin C is a potent antioxidant and cofactor for collagen synthesis, catecholamine production, and iron absorption. Cyanocobalamin and Folic Acid are interdependent cofactors in DNA synthesis and homocysteine metabolism; deficiency leads to megaloblastic anemia. Niacinamide (the amide form of Vitamin B3) is a precursor to NAD and NADP, coenzymes critical for redox reactions and cellular energy production.
Pregnancy: Category A (Indian FDA). This combination, particularly the 0.7mg Folic Acid, is beneficial in pregnancy for preventing neural tube defects (NTDs) and supporting increased nutritional demands. Should be used under medical supervision as part of prenatal care.
Driving: No known effects on driving ability.
| Levodopa | Vitamin B6 (if present) can decrease efficacy of Levodopa. Niacinamide may also interfere. Effect not significant with this specific combo but caution advised. | Moderate |
| Methotrexate | Folic Acid may reduce the anti-folate efficacy of Methotrexate in cancer chemotherapy. However, it is used to mitigate toxicity in rheumatoid arthritis treatment. Consult physician. | Major |
| Phenytoin / Phenobarbital | These anticonvulsants can reduce serum folate levels. Folic Acid supplementation may be needed but can also decrease phenytoin levels, potentially reducing seizure control. | Moderate |
| Chloramphenicol | May antagonize the hematopoietic response to Cyanocobalamin and Folic Acid in treating anemia. | Moderate |
| Proton Pump Inhibitors (Omeprazole, etc.) | Long-term use reduces gastric acid, impairing protein-bound B12 release from food, but not absorption of supplemental crystalline B12 in this formulation. | Minor |
| Metformin | Long-term use is associated with reduced Vitamin B12 absorption. This supplement can help correct deficiency. | Moderate |
Same composition (Vitamin C (150mg) + Thiamine(Vitamin B12) (2500mcg) + Folic Acid (0.7mg) + Niacinamide (12mg)), different brands: