Sorbitol Solution (1.2%) is a sterile, non-pyrogenic, aqueous solution of sorbitol, a hexahydric sugar alcohol (polyol). It is primarily used as an irrigating fluid in urological procedures, particularly Transurethral Resection of the Prostate (TURP) and other endoscopic surgeries. Its 1.2% concentration is slightly hypotonic to plasma, providing a clear surgical field with minimal risk of hemolysis when absorbed systemically. It is not intended for intravenous injection or oral consumption as a laxative, which uses higher concentrations.
Adult: Dosage is not fixed. Used as a continuous irrigation fluid during surgery. Typical volumes range from 10 to 30 liters per procedure, depending on duration and vascularity of the surgical field. Irrigation pressure should be maintained as low as possible (typically 60-80 cm H2O) to minimize systemic absorption.
Note: For sterile irrigation only. Use with appropriate urological irrigation sets. Warm to room or body temperature before use to prevent patient hypothermia. Must be used with continuous flow to maintain visibility and regulate pressure. Never pressurize container excessively. Do not mix with other drugs unless compatibility is known.
As an irrigant, it provides a clear, electrolyte-free, non-conductive medium for endoscopic surgery using monopolar electrocautery. Its osmotic properties (when absorbed) draw fluid into the intravascular space, leading to diuresis. It is metabolized to fructose, bypassing the rate-limiting phosphofructokinase step of glycolysis.
Pregnancy: Category C (US FDA). Animal reproduction studies not conducted. Should be used during surgery only if clearly needed. Risk is related to potential maternal hyponatremia and fluid overload.
Driving: N/A for irrigant use. Post-procedure, patients may be sedated or affected by hyponatremia; standard post-anesthesia driving restrictions apply.
| Loop Diuretics (Furosemide) | Additive diuretic effect; may help excrete absorbed fluid and correct hyponatremia. Often used therapeutically if TURP syndrome occurs. | Moderate |
| Hypertonic Saline (3% NaCl) | Used to treat severe symptomatic hyponatremia resulting from massive sorbitol absorption. A direct therapeutic interaction. | Major |
| Other Irrigants (Glycine, Mannitol) | Not used concurrently. Different risk profiles for TURP syndrome. | N/A |
Same composition (Sorbitol Solution (1.2%)), different brands: