A balanced, multi-electrolyte intravenous solution designed to mimic the electrolyte composition of plasma. It is a sterile, non-pyrogenic, isotonic solution used for fluid and electrolyte replacement. The sodium lactate component is metabolized to bicarbonate, providing a mild alkalinizing effect, making it suitable for correcting mild metabolic acidosis associated with dehydration.
Adult: Dosage is highly individualized based on patient's age, weight, clinical condition, and fluid/electrolyte status. Typical maintenance: 1.5 to 3 liters per 24 hours. For replacement: Based on deficit calculation. Infusion rate: Usually 500 mL to 1000 mL over 2 to 8 hours. Maximum rate should not exceed 300-500 mL/hour in normovolemic adults unless in controlled resuscitation settings.
Note: For intravenous use only. Must be administered using sterile technique. Use a clean, non-pyrogenic administration set. Check for clarity and container integrity before use. Do not connect flexible plastic containers in series. Do not use if the solution is cloudy, contains particulate matter, or if the seal is broken. The infusion rate must be regulated by a healthcare professional based on patient response.
This solution restores intravascular volume, corrects electrolyte imbalances, and provides a substrate for bicarbonate generation. Sodium and chloride maintain extracellular fluid volume and osmotic pressure. Potassium is the principal intracellular cation. Calcium is essential for neuromuscular function, cardiac contractility, and blood coagulation. Sodium lactate is converted in the liver to bicarbonate, helping to correct mild acidosis.
Pregnancy: Category C: Animal reproduction studies have not been conducted. It is not known whether this formulation can cause fetal harm. Should be used during pregnancy only if clearly needed, such as for correction of maternal fluid/electrolyte imbalance. The solution contains electrolytes essential for fetal development.
Driving: No effect. The solution is administered in a clinical setting.
| Potassium-Sparing Diuretics (Spironolactone, Amiloride) | Increased risk of severe hyperkalemia. | Major |
| ACE Inhibitors (Ramipril, Enalapril) / ARBs (Losartan) | Increased risk of hyperkalemia. | Major |
| Cardiac Glycosides (Digoxin) | Hypokalemia or hypomagnesemia potentiates digoxin toxicity. Hypercalcemia can also increase digoxin toxicity. | Major |
| Corticosteroids (Prednisolone, Hydrocortisone) | May cause sodium and fluid retention. | Moderate |
| Neuromuscular Blocking Agents (e.g., Succinylcholine) | Hyperkalemia may enhance neuromuscular blockade. | Moderate |
| Tetracycline Antibiotics (IV) | Calcium chloride can form insoluble complexes with tetracyclines, reducing antibiotic efficacy. Do not mix in the same line. | Major |
Same composition (Sodium Chloride (0.49% w/v) + Sodium Lactate (0.39% w/v) + Potassium Chloride (0.075% w/v) + Calcium Chloride (0.048% w/v)), different brands: