Resveratrol is a natural polyphenolic stilbenoid found in grapes, berries, and peanuts. At a 350mg dose, it is primarily used as a dietary supplement and nutraceutical in India for its potent antioxidant, anti-inflammatory, and potential cardioprotective properties. It functions as a SIRT1 activator and modulates multiple signaling pathways, including NF-κB and Nrf2. It is not approved as a prescription drug by the CDSCO for any specific disease but is widely marketed as a health supplement.
Adult: 250mg to 500mg once daily, commonly 350mg once daily with a meal. Doses up to 1g daily have been used in studies.
Note: Administer orally with a meal containing fats to enhance absorption. Swallow the capsule/tablet whole with a full glass of water. Do not crush or chew unless specified.
Resveratrol exerts pleiotropic effects through multiple molecular targets. Its primary recognized action is the activation of Sirtuin 1 (SIRT1), a NAD+-dependent deacetylase involved in cellular stress resistance, metabolism, and aging. It also modulates the NF-κB pathway, reducing pro-inflammatory cytokine production (TNF-α, IL-6, IL-1β), and activates the Nrf2/ARE pathway, upregulating endogenous antioxidant enzymes (e.g., glutathione, SOD). It exhibits phytoestrogenic activity by weakly binding to estrogen receptors.
Pregnancy: Category N (Not classified by US FDA). Insufficient data. Use is not recommended during pregnancy due to phytoestrogen activity and lack of safety studies.
Driving: Unlikely to affect ability to drive or operate machinery.
| Warfarin, Acenocoumarol, Clopidogrel, Aspirin, NSAIDs | May potentiate antiplatelet/anticoagulant effect, increasing bleeding risk. | Moderate |
| Cytochrome P450 Substrates (e.g., Midazolam, Simvastatin, Cyclosporine) | Resveratrol may inhibit CYP3A4, CYP2C9, and CYP2D6, potentially increasing levels of these drugs. | Moderate |
| Antihypertensives (ACE inhibitors, ARBs, Beta-blockers) | Additive hypotensive effect possible. | Mild |
| Antidiabetic Drugs (Metformin, Insulin, Sulfonylureas) | May enhance hypoglycemic effect. | Moderate |
| Tamoxifen, Raloxifene | Potential antagonism of anti-estrogen therapy due to weak estrogenic activity. | Theoretical/Moderate |
Same composition (Resveratrol (350mg)), different brands: