Pegasis (Note: This is Peginterferon alfa-2a, a different molecule)

ℹ️ Why is it prescribed?

Pegasis (Note: This is Peginterferon alfa-2a, a different molecule) contains Pegylated Interferon Alpha 2B (50mcg). It is primarily used for:

• Chronic Hepatitis C (Genotype 1-6) in combination with Ribavirin and/or Direct-Acting Antivirals (DAAs) as per guidelines
• Chronic Hepatitis B (HBeAg positive or negative) with compensated liver disease and evidence of viral replication

Side Effects

• Influenza-like symptoms (fever, chills, headache, myalgia, arthralgia - often managed with pre-dose paracetamol)
• Fatigue, asthenia
• Injection site reactions (erythema, pain, swelling)
• Anorexia, nausea
• Alopecia (reversible)
• Mild psychiatric symptoms (irritability, insomnia)

Contraindications

• Known hypersensitivity to interferon alpha-2b, polyethylene glycol (PEG), or any component
• Autoimmune hepatitis or history of severe autoimmune disease
• Decompensated liver disease (Child-Pugh Class B & C) prior to or during treatment
• Severe pre-existing psychiatric conditions (e.g., severe depression, suicidal ideation, psychosis)
• Concurrent use with Telbivudine (risk of severe peripheral neuropathy)