Cefixime is a third-generation oral cephalosporin antibiotic with broad-spectrum bactericidal activity against Gram-negative bacteria, including beta-lactamase producing strains. It is widely used in India for treating community-acquired respiratory, urinary, and gastrointestinal infections due to its good oral bioavailability, convenient once-daily dosing, and established safety profile.
Adult: 200 mg orally every 12 hours OR 400 mg once daily. For uncomplicated gonorrhea: 400 mg as a single dose.
Note: Can be taken with or without food. Taking with food may minimize gastrointestinal upset. Tablet should be swallowed whole with a glass of water. For oral suspension, shake the bottle well before each use. Use the measuring spoon/cup provided. Complete the full prescribed course even if symptoms improve.
Cefixime is a bactericidal antibiotic. It inhibits bacterial cell wall synthesis by binding to one or more of the penicillin-binding proteins (PBPs) located inside the bacterial cell wall. This binding inhibits the final transpeptidation step of peptidoglycan synthesis, leading to the formation of a defective cell wall and subsequent osmotic lysis of the bacterium.
Pregnancy: Pregnancy Category B (US FDA). Animal studies have shown no risk, but adequate and well-controlled studies in pregnant women are lacking. Use only if clearly needed, weighing benefits against potential risks. Generally considered safe when indicated.
Driving: Dizziness has been reported. Patients should be cautioned about operating machinery or driving until they are sure cefixime does not make them dizzy.
| Warfarin and other Coumarin Anticoagulants | Cefixime may potentiate anticoagulant effect by reducing vitamin K-producing gut flora and possibly by other mechanisms, increasing risk of bleeding. | Major |
| Aminoglycosides (e.g., Gentamicin) | Increased potential for nephrotoxicity. Monitor renal function. | Moderate |
| Potent Diuretics (e.g., Furosemide) | May increase the risk of nephrotoxicity due to altered renal excretion. | Moderate |
| Probenecid | Inhibits renal tubular secretion of cefixime, leading to increased and prolonged blood levels of cefixime. | Moderate |
| Oral Contraceptives | Potential for reduced efficacy of oral contraceptives due to altered gut flora. Advise use of a non-hormonal backup method. | Moderate |
| Antacids containing Aluminum or Magnesium | May reduce the absorption rate of cefixime, but the overall extent of absorption is not significantly affected. | Minor |