A fixed-dose combination of water-soluble B-complex vitamins and a provitamin of pantothenic acid, formulated for the nutritional management and treatment of neuropathic pain, vitamin B deficiencies, and related conditions. It is widely used in the Indian market for its neurotropic and metabolic actions.
Adult: Typically 1 injection (2ml ampoule) intramuscularly or deep subcutaneous, once daily or on alternate days initially, followed by 1-2 times per week as maintenance. Oral formulations: 1 tablet/capsule once or twice daily. MUST follow specific brand prescribing information.
Note: For Injection: Administer by deep intramuscular (IM) or slow intravenous (IV) route as per brand instructions. Avoid subcutaneous route for volumes >1ml. For Oral: Take with or after food to minimize gastric discomfort. Do not crush or chew sustained-release formulations.
Combined action of essential cofactors in carbohydrate metabolism (B1), amino acid and neurotransmitter synthesis (B6), myelin synthesis and nerve regeneration (B12), cellular respiration (Nicotinamide), and coenzyme A synthesis for fatty acid metabolism (D-Panthenol). Synergistically supports nerve health and energy production.
Pregnancy: Category A (US FDA). Water-soluble vitamins cross placenta. This high-dose combination should be used only if clearly needed and under medical supervision. Routine supplementation in pregnancy is at much lower doses.
Driving: Usually no effect. Dizziness or somnolence, though rare, may impair ability. Patients should be cautious initially.
| Levodopa | Pyridoxine (>5mg) can increase peripheral decarboxylation of Levodopa, reducing its central efficacy in Parkinson's disease. | Major |
| Phenytoin / Phenobarbitone | Pyridoxine may decrease serum levels of these anticonvulsants. | Moderate |
| Isoniazid, Cycloserine, Penicillamine | These drugs are pyridoxine antagonists and can increase requirement for B6. | Moderate |
| Chloramphenicol | May antagonize the hematopoietic response to Vitamin B12. | Moderate |
| Proton Pump Inhibitors (e.g., Omeprazole) | Long-term use can reduce absorption of Vitamin B12. | Moderate |
Same composition (Thiamine(Vitamin B1) (100mg) + Vitamin B6 (Pyridoxine) (100mg) + Methylcobalamin (0.1mg) + Nicotinamide (50mg) + D-Panthenol (ml)), different brands: