A fixed-dose combination of essential water-soluble B-complex vitamins and a provitamin of pantothenic acid, formulated for the nutritional management and treatment of neuropathic pain, vitamin B deficiencies, and related conditions. It acts synergistically to support nerve health, energy metabolism, and cellular function.
Adult: One tablet/capsule once daily, or as directed by the physician. Often prescribed for 4-8 weeks initially, followed by maintenance.
Note: Administer orally after a meal to enhance tolerance and absorption. Swallow whole with a glass of water. Do not crush or chew unless specified (some brands are chewable).
Combined action targets multiple pathways in nerve health and energy metabolism. Thiamine (as TPP) is a coenzyme for pyruvate dehydrogenase and transketolase in carbohydrate metabolism. Pyridoxine (as PLP) is a cofactor for amino acid metabolism and neurotransmitter synthesis (GABA, serotonin). Methylcobalamin is essential for myelin synthesis, nucleic acid production, and conversion of homocysteine to methionine. Nicotinamide (as NAD/NADP) is crucial for redox reactions and cellular energy (ATP) production. D-Panthenol (as Coenzyme A) is vital for fatty acid metabolism and acetylcholine synthesis.
Pregnancy: Category A (Indian/old FDA). Vitamins B1, B6, B12, Nicotinamide, and Panthenol are considered safe in pregnancy at recommended dietary levels. However, this is a high-dose therapeutic combination. Use only if clearly needed and potential benefit justifies potential risk to the fetus. Consult physician.
Driving: Drowsiness and dizziness have been reported rarely. Patients should not drive or operate machinery if they experience these effects.
| Levodopa (without Carbidopa) | Pyridoxine increases peripheral decarboxylation of Levodopa, reducing its central efficacy and worsening Parkinsonian symptoms. | Major |
| Phenytoin / Phenobarbital | Pyridoxine may decrease serum levels of these anticonvulsants, potentially reducing seizure control. | Moderate |
| Isoniazid, Cycloserine, Penicillamine | These drugs are Pyridoxine antagonists and can increase requirement/deficiency. This combination can counteract that effect. | Moderate |
| Chloramphenicol | May antagonize the hematopoietic response to Vitamin B12 (Methylcobalamin). | Moderate |
| 5-Fluorouracil (Chemotherapy) | Thiamine may reduce the efficacy of 5-FU. Concurrent use should be monitored. | Moderate |
Same composition (Thiamine(Vitamin B1) (100mg) + Vitamin B6 (Pyridoxine) (50mg) + Methylcobalamin (0.1mg) + Nicotinamide (100mg) + D-Panthenol (5mg)), different brands: