A topical combination preparation containing a potent corticosteroid (Fluticasone Propionate) and a topical antibiotic (Mupirocin). It is primarily used for the treatment of inflammatory dermatoses with secondary bacterial infection, particularly those caused by Staphylococcus aureus and Streptococcus pyogenes. The combination provides anti-inflammatory, anti-pruritic, and antibacterial actions.
Adult: Apply a thin layer to the affected area 2-3 times daily. Rub gently. Duration: Usually 5-10 days, not to exceed 2 weeks.
Note: 1. Wash and dry hands and affected area. 2. Apply a pea-sized amount (or thin film) and rub in gently until it disappears. 3. Do not cover with occlusive dressings unless specifically advised by a doctor. 4. Avoid contact with eyes, nose, mouth, and mucous membranes. 5. Wash hands after application unless hands are the treated area.
Fluticasone Propionate binds to cytoplasmic glucocorticoid receptors, leading to the synthesis of anti-inflammatory proteins (lipocortin) and inhibition of the production of pro-inflammatory mediators (prostaglandins, leukotrienes, cytokines). Mupirocin inhibits bacterial protein synthesis by reversibly and specifically binding to bacterial isoleucyl-tRNA synthetase, preventing incorporation of isoleucine into protein chains.
Pregnancy: Category C (US FDA). Animal studies show risk; no adequate human studies. Use only if potential benefit justifies potential fetal risk. Avoid large amounts or long-term use. Topical corticosteroids can be absorbed in amounts sufficient to cause systemic effects.
Driving: No effect on ability to drive or operate machinery.
| Other Topical Corticosteroids | Increased risk of local and systemic steroid side effects. | Major |
| Live Vaccines (e.g., Smallpox, BCG) | Risk of disseminated infection due to immunosuppression from systemic absorption. | Major |
| CYP3A4 Inhibitors (e.g., Ketoconazole, Itraconazole, Ritonavir) | May increase systemic levels of fluticasone if absorbed, increasing risk of steroid side effects. | Moderate |
Same composition (Fluticasone Propionate (0.005% w/w) + Mupirocin (2% w/w)), different brands: