A fixed-dose combination product primarily used as an antacid, electrolyte replenisher, and local analgesic for gastrointestinal discomfort. Magnesium carbonate neutralizes gastric acid, potassium chloride corrects hypokalemia, and procaine provides local anesthetic action on the gastric mucosa to relieve pain associated with hyperacidity and gastritis.
Adult: 1-2 tablets, to be chewed or sucked, 3-4 times daily, preferably 1 hour after meals and at bedtime, or as directed by the physician. Maximum: 8 tablets in 24 hours.
Note: Tablets should be chewed thoroughly or allowed to dissolve slowly in the mouth. Follow with a glass of water. Do not swallow whole. To be taken 1-2 hours apart from other oral medications (especially tetracyclines, fluoroquinolones, iron supplements, bisphosphonates) to avoid impaired absorption.
Magnesium carbonate reacts with hydrochloric acid in the stomach to form magnesium chloride, water, and carbon dioxide, thereby neutralizing excess acid and raising gastric pH. Potassium chloride directly supplies potassium ions to correct or prevent hypokalemia. Procaine, a local anesthetic, is intended to block sodium channels in the nerve endings of the gastric mucosa, providing temporary relief from pain associated with acid irritation, gastritis, or ulcers.
Pregnancy: Category C (US FDA). Magnesium carbonate and potassium chloride may be used if clearly needed, but data on procaine in pregnancy is limited. Use only if potential benefit justifies potential risk to the fetus. Avoid in first trimester unless essential.
Driving: Unlikely to affect driving ability. However, if symptoms of hypermagnesemia (drowsiness, dizziness) occur, patient should not drive or operate machinery.
| Tetracycline antibiotics (Doxycycline, Tetracycline) | Markedly decreased absorption of tetracyclines due to chelation by magnesium. | Major |
| Fluoroquinolone antibiotics (Ciprofloxacin, Levofloxacin) | Decreased absorption due to chelation. | Major |
| Bisphosphonates (Alendronate) | Severely reduced absorption. | Major |
| Iron supplements | Reduced absorption of oral iron. | Moderate |
| Digoxin | Hyperkalemia can increase risk of digoxin toxicity. Hypomagnesemia (if stopped abruptly) can also potentiate digoxin toxicity. | Major |
| Potassium-sparing diuretics (Spironolactone, Amiloride) | Increased risk of severe hyperkalemia. | Major |
| ACE inhibitors/ARBs (Ramipril, Losartan) | Increased risk of hyperkalemia. | Moderate |
| Neuromuscular blockers (Succinylcholine) | Procaine may potentiate neuromuscular blockade. | Moderate |
| Sulfonamides | PABA (procaine metabolite) may antagonize antibacterial action of sulfonamides. | Moderate |