A fixed-dose combination of two essential B vitamins. Nicotinamide (Vitamin B3 amide) is a precursor to NAD+ and NADP+, crucial for cellular energy metabolism and DNA repair. Methylcobalamin (Vitamin B12) is the active coenzyme form of B12, essential for neurological function, red blood cell formation, and myelin synthesis. This combination is primarily used for nutritional supplementation and managing symptoms of B-complex deficiency, particularly those with neuropathic components.
Adult: One tablet daily, or as directed by the physician. Typically taken after a meal.
Note: Administer orally with a glass of water, preferably after a meal to enhance tolerance and absorption. The tablet should not be crushed or chewed unless specified by the manufacturer. Consistent daily intake is more important than timing.
The combination works synergistically to support cellular metabolism and neurological health. Nicotinamide serves as an amide precursor to Nicotinamide Adenine Dinucleotide (NAD+) and its phosphate form (NADP+). These coenzymes are vital for over 400 enzymatic reactions, including glycolysis, TCA cycle, fatty acid oxidation, and oxidative phosphorylation (energy production). NAD+ is also a substrate for PARP enzymes (involved in DNA repair) and sirtuins (regulating gene expression, aging). Methylcobalamin is the metabolically active form of Vitamin B12. It acts as a cofactor for methionine synthase, converting homocysteine to methionine, which is crucial for DNA/RNA synthesis, neurotransmitter production, and myelin maintenance. It also aids in the conversion of methylmalonyl-CoA to succinyl-CoA, important for fatty acid and amino acid metabolism.
Pregnancy: Category A (Indian/US FDA equivalent). Both vitamins are considered safe in pregnancy at recommended dietary levels. This pharmacological dose should be used only if clearly needed and under medical supervision. Essential for fetal neurological development.
Driving: No known effects on driving ability. Dizziness is a rare side effect.
| Chloramphenicol | May interfere with the hematological response to Methylcobalamin. | Moderate |
| Proton Pump Inhibitors (Omeprazole, Pantoprazole) | Long-term use reduces gastric acid, impairing release of protein-bound B12 from food, potentially worsening deficiency. The high dose in this formulation may partially overcome this. | Moderate |
| Metformin | Chronic use is associated with reduced Vitamin B12 absorption, potentially increasing requirement. | Moderate |
| Aminosalicylic acid (PAS), Colchicine | May reduce absorption of Methylcobalamin. | Moderate |
| Alcohol (Chronic abuse) | Impairs absorption and increases excretion of both B12 and B3. | Moderate |
Same composition (Nicotinamide (12mg) + Methylcobalamin (1000mcg)), different brands: