Levodropropizine is the levo-isomer of dropropizine, a non-opioid, peripherally-acting antitussive agent. It acts by inhibiting sensory neuropeptide release from C-fibers in the bronchial mucosa, thereby reducing cough reflex sensitivity. It is widely used in India for the symptomatic treatment of acute and chronic non-productive cough associated with various respiratory conditions, offering efficacy with a favorable safety profile and minimal central nervous system depression.
Adult: 30 mg (5 ml) three times daily. Maximum: 180 mg/day.
Note: For oral use only. Use the measuring cup or spoon provided. Can be taken with or without food. Shake the bottle well before each use. Maintain adequate hydration.
Levodropropizine selectively inhibits the release of sensory neuropeptides (such as Substance P) from unmyelinated C-fibers in the bronchial mucosa. This action reduces the sensitivity of the cough reflex arc at the peripheral level, without depressing the central cough center in the medulla oblongata.
Pregnancy: Category B3 (as per some references). Animal studies are insufficient. There are no adequate and well-controlled studies in pregnant women. Use only if clearly needed and potential benefit justifies potential risk to the fetus, especially in the first trimester.
Driving: May cause dizziness or somnolence. Patients should be cautioned against driving or operating machinery until they know how the medication affects them.
| CNS Depressants (e.g., Alprazolam, Diazepam, Zolpidem, Phenobarbital) | Additive sedative effect, increased risk of drowsiness and impaired psychomotor performance. | Moderate |
| Alcohol | Potentiates CNS depressant effects, leading to increased sedation and dizziness. | Moderate |
| MAO Inhibitors (e.g., Phenelzine, Selegiline) | Theoretical risk of serotonin syndrome due to structural similarity to phenylpiperazine class. Avoid combination. | Major |
| Other Antitussives (e.g., Codeine, Dextromethorphan) | Increased antitussive effect, but also increased risk of side effects. Generally not recommended. | Moderate |