Lactobacillus (60Million spores) is a probiotic preparation containing viable, lyophilized spores of Lactobacillus species, primarily Lactobacillus sporogenes (now taxonomically reclassified as Bacillus coagulans). Each dose delivers 60 million colony-forming units (CFUs) of these acid-resistant, spore-forming bacteria. In the Indian context, it is widely used as a gut microbiota modulator for managing various gastrointestinal disorders, antibiotic-associated diarrhea, and for general gut health. The spore form ensures survival through the acidic gastric environment, allowing for effective colonization in the intestines.
Adult: 60 Million spores (1 capsule/sachet) orally, twice daily. For acute diarrhea: Continue for 2-3 days after symptoms resolve. For antibiotic-associated diarrhea: Continue for the duration of antibiotic therapy and 5-7 days after.
Note: Take with or without food. Preferably take with a glass of water or milk at room temperature/cold. DO NOT mix with hot liquids or food (>40°C). If taking antibiotics, maintain a gap of 2-3 hours. Capsules can be opened and mixed with cold water, yogurt, or formula for those who cannot swallow capsules.
Lactobacillus spores germinate in the intestine into vegetative cells. These cells exert beneficial effects through multiple mechanisms: 1) Competitive exclusion of pathogenic bacteria for nutrients and adhesion sites on the intestinal mucosa. 2) Production of bacteriocins and lactic acid, creating an acidic environment unfavorable for pathogens like Escherichia coli, Salmonella, and Clostridium difficile. 3) Modulation of the host immune response by enhancing secretory IgA production and cytokine regulation. 4) Aid in the digestion of lactose and production of certain B vitamins.
Pregnancy: Category A: Considered safe. Numerous studies and meta-analyses have not shown teratogenic or harmful effects. Often used for pregnancy-related constipation and gut health. However, use should be under medical advice.
Driving: No effect. Safe to drive and operate machinery.
| Antibiotics (e.g., Ciprofloxacin, Amoxicillin) | Concurrent administration may reduce probiotic viability. Probiotics may also reduce antibiotic efficacy if taken together. | Moderate |
| Antifungals (e.g., Fluconazole) | May reduce viability of the probiotic organism. | Moderate |
| Immunosuppressants (e.g., Tacrolimus, Cyclosporine) | Increased risk of probiotic-derived infection in these patients. Use with caution. | High |
| Sulfasalazine | Probiotics may enhance the breakdown of sulfasalazine to 5-ASA, potentially altering its local effect. Clinical significance is unclear. | Low |
Same composition (Lactobacillus (60Million spores)), different brands: