A balanced, multi-electrolyte intravenous solution designed for the correction of dehydration, electrolyte imbalances, and metabolic acidosis. It is a modified Ringer's Lactate solution, providing sodium, potassium, calcium, and lactate (a bicarbonate precursor) in physiological proportions. It is a cornerstone therapy in fluid resuscitation, perioperative care, and management of conditions involving fluid loss.
Adult: Highly individualized based on clinical condition, age, weight, and ongoing losses. General range: 500 mL to 3000 mL per 24 hours. For resuscitation: Boluses of 500-1000 mL may be given rapidly, repeated based on response. For maintenance: 1.5-3.0 mL/kg/hour.
Note: For intravenous use only. Must be administered using sterile technique. Use a large vein to avoid phlebitis. The infusion rate is determined by the patient's condition. Use an infusion pump for precise control, especially in pediatric and critical care settings. Check for particulate matter and discoloration before use.
This polyionic solution works by directly replenishing intravascular volume and correcting deficits of essential electrolytes (Na+, K+, Ca2+, Cl-). Sodium Lactate acts as a bicarbonate precursor. Upon infusion, lactate anions are metabolized in the liver via the Krebs cycle, consuming hydrogen ions and generating bicarbonate (HCO3-), thereby raising blood pH and correcting metabolic acidosis.
Pregnancy: Category C (US FDA). Should be used only if clearly needed. No well-controlled studies in pregnant women. Electrolyte imbalances can affect both mother and fetus. Benefits must outweigh risks.
Driving: No effect. The solution is used in a clinical setting and does not impair neurological function relevant to driving.
| Potassium-Sparing Diuretics (Spironolactone, Amiloride) | Increased risk of severe hyperkalemia. | Major |
| ACE Inhibitors (Ramipril, Enalapril) / ARBs (Losartan) | Increased risk of hyperkalemia. | Major |
| Cardiac Glycosides (Digoxin) | Hypercalcemia can potentiate digoxin toxicity, leading to arrhythmias. | Major |
| Corticosteroids (Prednisolone) | May cause sodium and fluid retention, antagonizing the solution's goal. | Moderate |
| IV Calcium Channel Blockers (e.g., Verapamil) | Potential pharmacological antagonism; monitor cardiac function. | Moderate |
Same composition (Sodium Chloride (0.6gm) + Sodium Lactate (0.32gm) + Potassium Chloride (40mg) + Calcium Chloride (27mg)), different brands: