Myo-Inositol is a naturally occurring isomer of inositol, a carbocyclic sugar polyol and a member of the vitamin B complex family. It functions as a second messenger in insulin signal transduction and follicular gonadotropin pathways. In the Indian context, it is widely used as a nutritional supplement and therapeutic agent for Polycystic Ovary Syndrome (PCOS), metabolic syndrome, and as an adjuvant in infertility management. It is considered a safe insulin sensitizer and oocyte quality enhancer.
Adult: For PCOS/Metabolic Syndrome: 2000-4000 mg per day in divided doses (e.g., 500mg capsules: 2 caps twice daily). Common Indian regimen: 2g (2000mg) daily.
Note: Administer orally with or without food. Taking with meals may reduce minor GI upset. Capsules/tablets should be swallowed whole with a glass of water. Consistent daily intake is important for therapeutic effect.
Myo-Inositol acts as a precursor for the synthesis of membrane phosphatidylinositol and inositol phosphoglycan (IPG) second messengers. In insulin-sensitive tissues, IPG mediates insulin's action on metabolic enzymes, improving glucose uptake and utilization, thereby reducing insulin resistance. In the ovary, it improves follicular sensitivity to Follicle-Stimulating Hormone (FSH), promotes oocyte maturation, and restores ovulation. It also modulates neurotransmitter (serotonin) receptor sensitivity.
Pregnancy: Category N (Not classified by US FDA). Considered safe and often used in pregnancy for women with PCOS to reduce risk of gestational diabetes. Numerous studies show no teratogenic effects. Consult physician.
Driving: No effect on driving ability. Dizziness is a rare side effect.
| Lithium | Myo-Inositol may reduce the efficacy of lithium by interfering with its intracellular second messenger pathway, potentially leading to recurrence of manic symptoms. | Moderate |
| Antidiabetic Drugs (Metformin, Sulfonylureas, Insulin) | Additive glucose-lowering effect; may increase risk of hypoglycemia. Monitor blood glucose levels closely. | Moderate |
| Selective Serotonin Reuptake Inhibitors (SSRIs) e.g., Sertraline, Escitalopram | Theoretical additive serotonergic effect. Clinical significance is unclear. | Mild |
Same composition (Myo-Inositol (500mg)), different brands: